ID C1H2Q7_PARBA Unreviewed; 504 AA.
AC C1H2Q7;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Trehalose-6-phosphate synthase {ECO:0000256|RuleBase:RU362045};
DE EC=2.4.1.15 {ECO:0000256|RuleBase:RU362045};
DE AltName: Full=UDP-glucose-glucosephosphate glucosyltransferase {ECO:0000256|RuleBase:RU362045};
GN ORFNames=PAAG_05050 {ECO:0000313|EMBL:EEH34001.2};
OS Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides
OS brasiliensis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX NCBI_TaxID=502779 {ECO:0000313|EMBL:EEH34001.2, ECO:0000313|Proteomes:UP000002059};
RN [1] {ECO:0000313|EMBL:EEH34001.2, ECO:0000313|Proteomes:UP000002059}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-826 / Pb01 {ECO:0000313|Proteomes:UP000002059};
RX PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT "Comparative genomic analysis of human fungal pathogens causing
RT paracoccidioidomycosis.";
RL PLoS Genet. 7:E1002345-E1002345(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-
CC trehalose 6-phosphate + H(+) + UDP; Xref=Rhea:RHEA:18889,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:58429,
CC ChEBI:CHEBI:58885, ChEBI:CHEBI:61548; EC=2.4.1.15;
CC Evidence={ECO:0000256|ARBA:ARBA00001516,
CC ECO:0000256|RuleBase:RU362045};
CC -!- PATHWAY: Carbohydrate biosynthesis. {ECO:0000256|ARBA:ARBA00024331}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 20 family.
CC {ECO:0000256|RuleBase:RU362045}.
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DR EMBL; KN294004; EEH34001.2; -; Genomic_DNA.
DR RefSeq; XP_015699683.1; XM_015845457.1.
DR AlphaFoldDB; C1H2Q7; -.
DR STRING; 502779.C1H2Q7; -.
DR GeneID; 9096156; -.
DR KEGG; pbl:PAAG_05050; -.
DR VEuPathDB; FungiDB:PAAG_05050; -.
DR eggNOG; KOG1050; Eukaryota.
DR HOGENOM; CLU_002351_7_2_1; -.
DR OMA; RTIWPLF; -.
DR OrthoDB; 1023at2759; -.
DR Proteomes; UP000002059; Partially assembled WGS sequence.
DR GO; GO:0003825; F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity; IEA:UniProtKB-EC.
DR GO; GO:0005992; P:trehalose biosynthetic process; IEA:InterPro.
DR CDD; cd03788; GT20_TPS; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR001830; Glyco_trans_20.
DR InterPro; IPR012766; Trehalose_OtsA.
DR NCBIfam; TIGR02400; trehalose_OtsA; 1.
DR PANTHER; PTHR10788:SF106; BCDNA.GH08860; 1.
DR PANTHER; PTHR10788; TREHALOSE-6-PHOSPHATE SYNTHASE; 1.
DR Pfam; PF00982; Glyco_transf_20; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000256|RuleBase:RU362045};
KW Reference proteome {ECO:0000313|Proteomes:UP000002059};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU362045}.
FT REGION 481..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 504 AA; 56539 MW; 52057992FF09BAE0 CRC64;
MMPGCSLFPN RLPITIKRSD DGKYEFSMSS GGLVSGLSGL SKSTTFQWYG WPGLQVPEDE
ILLLKKRLAE EYDAVPVLID DNLADKHYNG FSNSILWPLF HYHPGEITFD ESAWFAYRDA
NRLFAKAIAN DVKDGDLVWV HDYHLMLLPA MLREEIGTSK KNVKIGFFLH TPFPSSEIYR
ILPVRNELLL GVLHCDLIGF HTYDYARHFL SSCSRILGLS TTPNGVEFQG KVIAVGAFPI
GIDPDKFSEG LKKEKVQKRI AALEQKFQGV KLMVGVDRLD YIKGVPQKLH ALEVFLTDHP
EWIGKVVLVQ VAVPSRQDVE EYQNLRAVVN ELVGRINGKF GTVEFMPIHF MHKSVNFDEL
IALYAVSDVC VVSSTRDGMN LVSYEYIATQ KKRHGCLVLS EFAGAAQSLN GSIIVNPWNT
EELANAFQEA VTMSDEQRAL NFSKLDKYVS KYTSAFWGQS FVSELTRISA HGEKKLRLRN
TSAIPSDLSH GKENDIPPAT PDGN
//
