ID C1H4Z0_PARBA Unreviewed; 672 AA.
AC C1H4Z0;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 2.
DT 03-MAY-2023, entry version 57.
DE SubName: Full=Vacuolar conductance {ECO:0000313|EMBL:EEH34784.2};
GN ORFNames=PAAG_05831 {ECO:0000313|EMBL:EEH34784.2};
OS Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides
OS brasiliensis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX NCBI_TaxID=502779 {ECO:0000313|EMBL:EEH34784.2, ECO:0000313|Proteomes:UP000002059};
RN [1] {ECO:0000313|EMBL:EEH34784.2, ECO:0000313|Proteomes:UP000002059}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-826 / Pb01 {ECO:0000313|Proteomes:UP000002059};
RX PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT "Comparative genomic analysis of human fungal pathogens causing
RT paracoccidioidomycosis.";
RL PLoS Genet. 7:E1002345-E1002345(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KN294007; EEH34784.2; -; Genomic_DNA.
DR RefSeq; XP_015699918.1; XM_015845692.1.
DR AlphaFoldDB; C1H4Z0; -.
DR STRING; 502779.C1H4Z0; -.
DR GeneID; 9095443; -.
DR KEGG; pbl:PAAG_05831; -.
DR VEuPathDB; FungiDB:PAAG_05831; -.
DR eggNOG; ENOG502QTER; Eukaryota.
DR HOGENOM; CLU_014123_0_0_1; -.
DR OMA; YQKCIKY; -.
DR OrthoDB; 1387259at2759; -.
DR Proteomes; UP000002059; Partially assembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR013122; PKD1_2_channel.
DR PANTHER; PTHR35859:SF5; ION_TRANS DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR35859; NONSELECTIVE CATION CHANNEL PROTEIN; 1.
DR Pfam; PF08016; PKD_channel; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002059};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 235..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 296..315
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 374..394
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 435..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 490..510
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 522..541
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 264..462
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
FT REGION 620..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 672 AA; 76457 MW; A1256E8AC31E5C33 CRC64;
MVRWSHLFSS DDRRRHRQLH EGRRLLPVRR NEAIPPALPA KEVTKVALRL KYQIEQVIPC
ELEEKALTKP NSSVITKAVI QTAREAAGEY NKACVVYCLL VCLRWFKLQA RVELWDSDLH
ELRAVVCEVL AKRIIEAEED QDYLMQEVLL KRYAIFLDGE DTPPVNVIER AVDLHALRVI
GSSGYQKCIK YLWHGWLCQD DKDPSTFIEN PERVNTHYWA HFNPDRLRAP IYQNAVQIFF
SLLYLALYTG VINTINPSGD LDIVEGLLYL MTLGFICDEI AKFWKVGRFY FGFWNAFNST
LYTLLLVSFI LRIVALTRSS DSHDAERMKF NALSYNFLAF SAPMFWGRIL LFLDTYRFFG
AMLVVLKVMM KESLIFFALL AVVIIGFLQG FMGMDQADPG NAMTPSVILQ GMANTIMQSP
DFSVFQEFSA PFGILLYYLF TFVVMVILLN ILIALYNSAY EDITGNATDE YMALFAHRTM
QFVRAPDENV FIAPFNLIEI FLLILPFEWW LSTDKYERLN HYVMGVIYSP LLFITAFIET
LNARRIRLNR RLGEEDDDVL EEWQAAAQDL NIDFEADSWD LKVAKTKPNV EVDPCVLEVR
ELKGQVVELM ELTKKLKEEV EAGRGSSGGG SGVAVVNGVH EAGDEGSGDG SGSGNAERLE
DINGEGDGDG QG
//