ID   C1H6L7_PARBA            Unreviewed;       865 AA.
AC   C1H6L7;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 2.
DT   27-MAR-2024, entry version 57.
DE   SubName: Full=Sulfatase domain-containing protein {ECO:0000313|EMBL:EEH35361.2};
GN   ORFNames=PAAG_06408 {ECO:0000313|EMBL:EEH35361.2};
OS   Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides
OS   brasiliensis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX   NCBI_TaxID=502779 {ECO:0000313|EMBL:EEH35361.2, ECO:0000313|Proteomes:UP000002059};
RN   [1] {ECO:0000313|EMBL:EEH35361.2, ECO:0000313|Proteomes:UP000002059}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-826 / Pb01 {ECO:0000313|Proteomes:UP000002059};
RX   PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA   Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA   Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA   Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA   Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA   Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA   Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA   Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA   Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT   "Comparative genomic analysis of human fungal pathogens causing
RT   paracoccidioidomycosis.";
RL   PLoS Genet. 7:E1002345-E1002345(2011).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KN294009; EEH35361.2; -; Genomic_DNA.
DR   RefSeq; XP_015700107.1; XM_015845881.1.
DR   AlphaFoldDB; C1H6L7; -.
DR   GeneID; 9094834; -.
DR   KEGG; pbl:PAAG_06408; -.
DR   VEuPathDB; FungiDB:PAAG_06408; -.
DR   eggNOG; ENOG502SJFZ; Eukaryota.
DR   HOGENOM; CLU_016056_0_0_1; -.
DR   OMA; KSAVMNY; -.
DR   OrthoDB; 69264at2759; -.
DR   Proteomes; UP000002059; Partially assembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR000917; Sulfatase_N.
DR   PANTHER; PTHR43751:SF3; N-ACETYLGALACTOSAMINE 6-SULFATASE (GALNS); 1.
DR   PANTHER; PTHR43751; SULFATASE; 1.
DR   Pfam; PF00884; Sulfatase; 1.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002059};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        74..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        121..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          564..730
FT                   /note="Sulfatase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00884"
FT   REGION          302..325
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        304..325
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   865 AA;  97333 MW;  82F7750090334543 CRC64;
     MNPFSFRIFQ PLIFSILVVA IISSKLLHLF QHAHSIPLPR FILYFFTFFI QDCFLIIVHR
     LLLYGQSRNI QTIIGLTIGV ILAIVSLSAS AAQFGFYYVT GGELQWDAAG SVANDPAAVR
     LMLSGIAPVS ISGLALFLVS WSITPVLYIK VGGWLVVVWN LVSPGNWDVL LPVIRTKSDF
     SHQKAIRLWP LCVLTTICSL TLLQFVRPAV PYDHISATLP VAMTRMIRSK SNSCPRHLLP
     NGESFPLPDL LTKDRWIMPH DNYKGWAPGQ ENFFVQQYAE RQRKWIPDTL PAGFERWNKK
     QKLGQPLAKN NSAPTKNSKN KCPNMGGTNH YNPVADPLRI SNLNLAPLEE LRKAFKDVLI
     SHVVLVTLES TRKDMFPIMD GSYLHRKILG SYKGGDENKA LVNEKLSQLT RVAEQVTGQS
     FFSSAEPQTQ PELLPGVWRD QADPGMGGIN VVGAVTGSTL SFKSVIGSHC GVGPLPRDFL
     EEVNAQIYQP CIPQIMELFN NQKKSNDGKD GKESLLEHRA SVHRRKWESV FVQSITDQYD
     RQDELNRHMN FGQSFVRETL DNKTSKYYTP DAEEINYFGY AETAVKPFLR DLISDVIANN
     KRLFLSHFTS TTHHPWGVPK SFNKTEYMGS EGSHEHMNDF LNVIHYDDMW LGELLGLLDE
     HGIANETLVV MVGDHGQAFA EDSKLTGTYE NAHISNFRVP LVFRHPHLPR LQINANATSM
     SILPTILDLL VSTNSLDAVD TSAAADLMHD YEAQSLLRPY QTSLNGRQAW NFGVINAGGA
     LLSIISAAVP YRIVIPLSGN FMFRFTNTAT DPNELHPLEK WTLIDLVKVV RQRYGQEAAN
     WASEADAIGR WWATEMHRLY NYNSR
//