ID   C1H9I3_PARBA            Unreviewed;       705 AA.
AC   C1H9I3;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 2.
DT   27-MAR-2024, entry version 60.
DE   SubName: Full=Prenylcysteine oxidase {ECO:0000313|EMBL:EEH37006.2};
GN   ORFNames=PAAG_07424 {ECO:0000313|EMBL:EEH37006.2};
OS   Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides
OS   brasiliensis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX   NCBI_TaxID=502779 {ECO:0000313|EMBL:EEH37006.2, ECO:0000313|Proteomes:UP000002059};
RN   [1] {ECO:0000313|EMBL:EEH37006.2, ECO:0000313|Proteomes:UP000002059}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-826 / Pb01 {ECO:0000313|Proteomes:UP000002059};
RX   PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA   Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA   Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA   Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA   Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA   Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA   Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA   Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA   Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT   "Comparative genomic analysis of human fungal pathogens causing
RT   paracoccidioidomycosis.";
RL   PLoS Genet. 7:E1002345-E1002345(2011).
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- SIMILARITY: Belongs to the prenylcysteine oxidase family.
CC       {ECO:0000256|ARBA:ARBA00009967}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KN294015; EEH37006.2; -; Genomic_DNA.
DR   RefSeq; XP_015700655.1; XM_015846220.1.
DR   AlphaFoldDB; C1H9I3; -.
DR   STRING; 502779.C1H9I3; -.
DR   GeneID; 9093863; -.
DR   KEGG; pbl:PAAG_07424; -.
DR   VEuPathDB; FungiDB:PAAG_07424; -.
DR   eggNOG; ENOG502QSHJ; Eukaryota.
DR   HOGENOM; CLU_021176_0_0_1; -.
DR   OMA; NMWAVEG; -.
DR   OrthoDB; 1334100at2759; -.
DR   Proteomes; UP000002059; Partially assembled WGS sequence.
DR   GO; GO:0001735; F:prenylcysteine oxidase activity; IEA:InterPro.
DR   GO; GO:0030328; P:prenylcysteine catabolic process; IEA:InterPro.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR010795; Prenylcys_lyase.
DR   InterPro; IPR017046; Prenylcysteine_Oxase.
DR   PANTHER; PTHR15944; FARNESYLCYSTEINE LYASE; 1.
DR   PANTHER; PTHR15944:SF0; PRENYLCYS_LYASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF13450; NAD_binding_8; 1.
DR   Pfam; PF07156; Prenylcys_lyase; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002059};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          299..692
FT                   /note="Prenylcysteine lyase"
FT                   /evidence="ECO:0000259|Pfam:PF07156"
FT   REGION          68..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   705 AA;  78199 MW;  71DE18E96C34344F CRC64;
     MIRYEVCEVE LSSRASFNGG DVIAGVLTLS QLEPVDLFSR SSSTLTLTDF GCVDLRQLIG
     RACITKGPDR PTSCAEAPHA QSRRAATTTQ KPRRRLPESK TSLYLSAYPP TIPRLSHHSE
     RALGVLLLLN GRTIVLFAIS RHYLGNPPQI EGERCQDAQV PLQVEPEPPQ APATVLSPTP
     DPAPAKKVAV IGAGSAGASA AYYLRQFTDF FSIPLNLTVY ERASYVGGRS TTVNLFDDPS
     LPVELGASIF VEVNKNLIRA TRKFGLKLRD SDFGQPKESI HSLGVWDGRE FEFLQERGGL
     YWWSIFKLIY RYGWAPMKTQ NLMKSTVNKF LKLYKFPYFP FQSLSDAAMS AGLAEATWTS
     GAEYLKDNGV SEQFAREIIQ ASTRVNYGQN LPLIHGLETM VCMATDGAVA VEGGNWQIFQ
     SMLNASKATV NLNSPVTSIE LSGNKTYKVT HRNPDNTLAE DTFDHVVIAN PFQFSNISIS
     PRLKRPIDSP RYVNLHVTIF ATPYKLSPSY FKMPADSFVP EVVLTTLPPD VKLGTRTDGV
     GPAQFWSIST LQKVQPPETT RNDLSPGPHY VYKIFSPKQL KASFLSQILG IDGVRLLDNN
     STANNNDDGG EATYRDDQSI ADISPSHISW SYEKVWQSYP YLYPRVTFED IKLAPNLWYT
     SGMESFISTM ETSSLSGMNV AALILSEWVS KFETKLKKYE DGGGY
//