ID C1HB01_PARBA Unreviewed; 423 AA.
AC C1HB01;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 2.
DT 24-JAN-2024, entry version 63.
DE RecName: Full=Enoyl reductase (ER) domain-containing protein {ECO:0000259|SMART:SM00829};
GN ORFNames=PAAG_07865 {ECO:0000313|EMBL:EEH37447.2};
OS Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides
OS brasiliensis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX NCBI_TaxID=502779 {ECO:0000313|EMBL:EEH37447.2, ECO:0000313|Proteomes:UP000002059};
RN [1] {ECO:0000313|EMBL:EEH37447.2, ECO:0000313|Proteomes:UP000002059}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-826 / Pb01 {ECO:0000313|Proteomes:UP000002059};
RX PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT "Comparative genomic analysis of human fungal pathogens causing
RT paracoccidioidomycosis.";
RL PLoS Genet. 7:E1002345-E1002345(2011).
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DR EMBL; KN294018; EEH37447.2; -; Genomic_DNA.
DR RefSeq; XP_015700790.1; XM_015846355.1.
DR AlphaFoldDB; C1HB01; -.
DR STRING; 502779.C1HB01; -.
DR GeneID; 9093433; -.
DR KEGG; pbl:PAAG_07865; -.
DR VEuPathDB; FungiDB:PAAG_07865; -.
DR eggNOG; KOG1198; Eukaryota.
DR HOGENOM; CLU_026673_3_3_1; -.
DR OMA; RFWVCGV; -.
DR OrthoDB; 2105283at2759; -.
DR Proteomes; UP000002059; Partially assembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd05289; MDR_like_2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR43482; PROTEIN AST1-RELATED; 1.
DR PANTHER; PTHR43482:SF1; PROTEIN AST1-RELATED; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002059}.
FT DOMAIN 77..416
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
FT REGION 31..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 78..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 423 AA; 46546 MW; ABE06E1B0F966FC0 CRC64;
MQPTPRTHTS IYAEQENIPP AMAALTLPLP TTHHYTTTNP PPPSTLIYTS THPTPTPTES
QYLLKILATA FCRGELGWSE TLRPPPSPTS TSTSASASAN QTQSQIQIQD FKRIPGHDVT
GIILSTPQVD EHSVTGPRFK VGDEVMGLLA FERDGGAADV AVAVEGELAF KPRNVGAAEG
ACLPLSALTG WQALFEQVGL RGVVMYSDDE DEERERVRQR ERDDEEKVKR ILVLNASGGV
GVMLCQLLRA KMLFGENGGQ RFWVCGVCSG RNMGFVRGEL GVDEVLDYTQ EKGLAEAFRK
RGWGPVDLVL DCVGGESLRQ VHDATVVRDG GFVVSIAQPI PEREPEWEGV RNEIERRLLT
SRFFIVRPDG EQLGKIGLLV EKGELRAFVA KEMGLYEGRE AMELVESGRM RGKVVLRVNY
YDP
//
