ID C1IPM5_9GAMM Unreviewed; 776 AA.
AC C1IPM5;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 13-SEP-2023, entry version 59.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982};
DE Flags: Fragment;
GN Name=mutS {ECO:0000313|EMBL:ACG63433.1};
OS Francisella philomiragia.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Thiotrichales;
OC Francisellaceae; Francisella.
OX NCBI_TaxID=28110 {ECO:0000313|EMBL:ACG63433.1};
RN [1] {ECO:0000313|EMBL:ACG63433.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCUG 19701 {ECO:0000313|EMBL:ACG63433.1};
RX PubMed=19187160; DOI=10.1111/j.1365-2672.2008.04092.x;
RA Ottem K.F., Nylund A., Karlsbakk E., Friis-Moller A., Kamaishi T.;
RT "Elevation of Francisella philomiragia subsp. noatunensis Mikalsen et al.
RT (2007) to Francisella noatunensis comb. nov. [syn. Francisella piscicida
RT Ottem et al. (2008) syn. nov.] and characterization of Francisella
RT noatunensis subsp. orientalis subsp. nov., two important fish pathogens.";
RL J. Appl. Microbiol. 106:1231-1243(2009).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|RuleBase:RU003756}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; EU682968; ACG63433.1; -; Genomic_DNA.
DR AlphaFoldDB; C1IPM5; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756}.
FT DOMAIN 662..678
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACG63433.1"
FT NON_TER 776
FT /evidence="ECO:0000313|EMBL:ACG63433.1"
SQ SEQUENCE 776 AA; 87659 MW; C19A8A7C00FEBD84 CRC64;
DILLFYRMGD FYELFFDDAK NAAELLDITL TARGKSNGDS IPMAGVPYHA AEGYIAKIVK
KGLSVAICEQ IGDPSTSKGP VERQVTRIIT PATVSEEAFL DSNQDSILVS IYEKNNKYHI
AYTSYTQGKI HLINTVTNSS DLKNQILKLS PQEIITNSNS LVEKNIFNKP VKVLEEWYFS
NFEAKKHILN SFDNSFANNI LNLYKKEQLT VIGSILAYLT NTLKSTPKHI SDILLDEDQN
ILNIDINSRN NLELDNNSKS SLLNIMDKCK TSLGSRLLRR YFKNPTRDLN KISLRHNVIK
SFKQHHYFLK IQDILSYIND IERIISRVAL GTVKPKDLVS LNSSLEQLPK LKSLLEEINT
SEIININNHI HQIDELTKLL NKAIVDNPPM TIRDGGVIKH GFDQELDELR GLKDNSYDFL
LKFETLQKQK TGINTLKVGY NRVHGYYIEL SKQYADKVPT EYIRRQTLKA SERYITDELK
AFEDKILSAK EKALAREKLI YDTLLNKVLE YYSQIQQTAA SIAKIDVLAN FAERAIKLNL
NQPKFNKAGK LDIKEARHLA IEQNIDEPFI PNDTLLSTDT YTLEIITGPN MGGKSTYMRQ
VAQLIFLAYI GSFVPASYAD IGDIDTIYTR IGASDDISSG RSTFMVEMTE TAYILNNATK
KSLVIMDEIG RGTSTFDGLS LAKACAEKFA KIGAMTLFAT HYFELTELVN QYPNTKNIHF
EAKEYKDNIY FMHKAVAGAA KKSYGIQVAK LAGISKDVLE SAKKNLANLE KGQDKL
//
