ID C1KA25_HAECO Unreviewed; 478 AA.
AC C1KA25;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Acetylcholine receptor DES-2-like protein {ECO:0000313|EMBL:ACO48374.1};
OS Haemonchus contortus (Barber pole worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX NCBI_TaxID=6289 {ECO:0000313|EMBL:ACO48374.1};
RN [1] {ECO:0000313|EMBL:ACO48374.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Hc-CRA AAD-mutant {ECO:0000313|EMBL:ACO48374.1};
RX PubMed=19360096; DOI=10.1371/journal.ppat.1000380;
RA Rufener L., Maser P., Roditi I., Kaminsky R.;
RT "Haemonchus contortus acetylcholine receptors of the DEG-3 subfamily and
RT their role in sensitivity to monepantel.";
RL PLoS Pathog. 5:E1000380-E1000380(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC {ECO:0000256|RuleBase:RU000687}.
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DR EMBL; FJ807331; ACO48374.1; -; mRNA.
DR AlphaFoldDB; C1KA25; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR CDD; cd18997; LGIC_ECD_nAChR; 1.
DR CDD; cd19051; LGIC_TM_cation; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945:SF410; ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-TYPE DES-2; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 2: Evidence at transcript level;
KW Ion channel {ECO:0000256|RuleBase:RU000687};
KW Ion transport {ECO:0000256|RuleBase:RU000687};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000687};
KW Receptor {ECO:0000313|EMBL:ACO48374.1};
KW Signal {ECO:0000256|RuleBase:RU000687};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000687};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU000687}; Transport {ECO:0000256|RuleBase:RU000687}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT CHAIN 20..478
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT /id="PRO_5022250804"
FT TRANSMEM 236..259
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 271..289
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 301..326
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 446..468
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT DOMAIN 25..235
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 242..460
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
SQ SEQUENCE 478 AA; 54610 MW; C718B43BBCFEFF65 CRC64;
MYALTLTIAA ALSAAMVAST PTQIQLVHDL LDKYDKKAKP MWDNTKPVNV SFTVSLYQIL
ELNEPQQFVL LNAWIIERWY DEFLYWSPME YQNITELRLP YDSIWLPDTT LYNSLVMKDD
DTRRLLNAKL TTDLQRRASL IELLYPTIYK FSCLLDLRFF PFDVQNCTMI FSSWTYDQTG
IDYFPASDEI SIANYLENEG WELLKTEVSR HEVKYSCCPN AYTLLHLTLY LRRKPLFYLV
NLIIPTSIIT LIAIVGFFTT SSASGMREEK VSLGITTLLS MSILMLMVSD QMPTTSTFIP
LIGWFILAMI MVISLGTVVS SIIIAVQKRG SLGERLSKRT LRIAKMIAYF TCTALPSHIE
KEQMMEAFDA VTPTGESVRT LKSAMDASKK WMSLRRPKNG VAVVSDKSTD ALIQMANSGA
ASIRHNRQLA VAEFEWLATV TERTCFVIFV LCFLIITIGI NMIGYVHWSK ADQRWKNQ
//
