ID C1KG54_STRMT Unreviewed; 568 AA.
AC C1KG54;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=LytB {ECO:0000313|EMBL:ACO37163.1};
DE EC=3.2.1.96 {ECO:0000313|EMBL:ACO37163.1};
DE SubName: Full=N-acetylmuramoyl-L-alanine amidase {ECO:0000313|EMBL:KYF33144.1};
DE EC=3.5.1.28 {ECO:0000313|EMBL:KYF33144.1};
GN Name=lytB {ECO:0000313|EMBL:ACO37163.1};
GN ORFNames=SMI10712_00819 {ECO:0000313|EMBL:KYF33144.1};
OS Streptococcus mitis.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=28037 {ECO:0000313|EMBL:ACO37163.1};
RN [1] {ECO:0000313|EMBL:ACO37163.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NCTC10712 {ECO:0000313|EMBL:ACO37163.1};
RX PubMed=19396958; DOI=10.1111/j.1574-6976.2009.00172.x;
RA Hakenbeck R., Madhour A., Denapaite D., Bruckner R.;
RT "Versatility of choline metabolism and choline-binding proteins in
RT Streptococcus pneumoniae and commensal streptococci.";
RL FEMS Microbiol. Rev. 33:572-586(2009).
RN [2] {ECO:0000313|EMBL:KYF33144.1, ECO:0000313|Proteomes:UP000075618}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=10712 {ECO:0000313|EMBL:KYF33144.1,
RC ECO:0000313|Proteomes:UP000075618};
RA Denapaite D., Rieger M., Koendgen S., Brueckner R., Ochigava I.,
RA Kappeler P., Maetz-Rensing K., Leendertz F., Hakenbeck R.;
RT "Highly variable Streptococcus oralis are common among viridans
RT streptococci isolated from primates.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 73 family.
CC {ECO:0000256|ARBA:ARBA00010266}.
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DR EMBL; FJ824668; ACO37163.1; -; Genomic_DNA.
DR EMBL; LROT01000028; KYF33144.1; -; Genomic_DNA.
DR AlphaFoldDB; C1KG54; -.
DR CAZy; GH73; Glycoside Hydrolase Family 73.
DR PATRIC; fig|28037.237.peg.1556; -.
DR Proteomes; UP000075618; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0004040; F:amidase activity; IEA:InterPro.
DR GO; GO:0033925; F:mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0008745; F:N-acetylmuramoyl-L-alanine amidase activity; IEA:UniProtKB-EC.
DR GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 1.10.530.10; -; 1.
DR Gene3D; 2.10.270.10; Cholin Binding; 2.
DR Gene3D; 2.20.120.10; Multimodular pneumococcal cell wall endolysin, domain 3; 2.
DR InterPro; IPR018337; Cell_wall/Cho-bd_repeat.
DR InterPro; IPR041074; LytB_SH3.
DR InterPro; IPR040742; LytB_WW-like.
DR InterPro; IPR002901; MGlyc_endo_b_GlcNAc-like_dom.
DR PANTHER; PTHR33308; PEPTIDOGLYCAN HYDROLASE FLGJ; 1.
DR PANTHER; PTHR33308:SF9; PEPTIDOGLYCAN HYDROLASE FLGJ; 1.
DR Pfam; PF01473; Choline_bind_1; 4.
DR Pfam; PF19085; Choline_bind_2; 1.
DR Pfam; PF01832; Glucosaminidase; 1.
DR Pfam; PF18342; LytB_SH3; 1.
DR Pfam; PF17890; WW_like; 1.
DR SMART; SM00047; LYZ2; 1.
DR SUPFAM; SSF69360; Cell wall binding repeat; 2.
DR PROSITE; PS51170; CW; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000313|EMBL:ACO37163.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:ACO37163.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..568
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002909773"
FT REPEAT 250..271
FT /note="Cell wall-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00591"
FT DOMAIN 438..568
FT /note="Mannosyl-glycoprotein endo-beta-N-
FT acetylglucosamidase-like"
FT /evidence="ECO:0000259|SMART:SM00047"
SQ SEQUENCE 568 AA; 65440 MW; 0BE68413D323480E CRC64;
MKKLRFIFLA LLFFLARPES AMASDGTWQG KQYLKADGSQ AANEWVFDTH YQSWFYIKAD
ANYAENEWLK QGDDYFYLKS GGYMAKSEWV EDKGVLYYLD QDGKMKRNAW LGASYVGATG
AKVIEDWVYD SQYDAWFYIK ADGQHAEKEW LQIKGKDYYF KSGGYLLTSQ WIEQAYVSTS
GAKVQQGWLF DKQYQSWFYI KENGNHADKE WIFENGHYYY LKSGGYMAAN EWILDKESWF
YLKSDGKMAE KEWVYDSKNQ AWYYFKSGGY MAKNETIDGH QLGNDGKWNK ESKTSSDYYQ
VLPVTANIYN ADGEKLSYIS QGSVVWLDKD RKSDDKRLAI TISGLSGYMK TEDLQALDAG
KDFIPYYESD GHRFYHYVAQ NASIPVAAHL SDMEVGKKYY SADGLHFDGF NLENPFLFKD
LTEATNYSAE DLDKVFSLLN INNSLLENKG STFKEAEEHY HINALYLLAH SALESDWGRS
KIAKDKNNFF GITAYDTTPY LSAKTFDDVD KGILGATKWI KENYIDRGRT FLGNKASGMN
VEYASDPYWG EKIASVMMKI NEKLGGKD
//
