ID   C1L3Z3_SCHJA            Unreviewed;        48 AA.
AC   C1L3Z3;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Schistosoma japonicum (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6182 {ECO:0000313|EMBL:CAX69421.1};
RN   [1] {ECO:0000313|EMBL:CAX69421.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Anhui {ECO:0000313|EMBL:CAX69421.1};
RX   DOI=10.1038/nature08140;
RA   Liu F., Zhou Y., Wang Z.Q., Lu G., Zheng H., Brindley P.J., McManus D.P.,
RA   Blair D., Zhang Q.H., Zhong Y., Wang S., Han Z.G., Chen Z.;
RT   "The Schistosoma japonicum genome reveals features of host-parasite
RT   interplay.";
RL   Nature 460:345-351(2009).
RN   [2] {ECO:0000313|EMBL:CAX69421.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Anhui {ECO:0000313|EMBL:CAX69421.1};
RA   Gang L.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; FN313687; CAX69421.1; -; mRNA.
DR   AlphaFoldDB; C1L3Z3; -.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629:SF63; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
PE   2: Evidence at transcript level;
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        12..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
SQ   SEQUENCE   48 AA;  5357 MW;  00FAB0672E82F489 CRC64;
     MRMGLSISGL YGGVVLAFIF AFWAILTVSI LLCMEGLSAF LHTLRLHW
//