ID C1L505_SCHJA Unreviewed; 770 AA.
AC C1L505;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Rab GTPase-binding effector protein 2 {ECO:0000256|ARBA:ARBA00019765};
OS Schistosoma japonicum (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6182 {ECO:0000313|EMBL:CAX69783.1};
RN [1] {ECO:0000313|EMBL:CAX69783.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Anhui {ECO:0000313|EMBL:CAX69783.1};
RX DOI=10.1038/nature08140;
RA Liu F., Zhou Y., Wang Z.Q., Lu G., Zheng H., Brindley P.J., McManus D.P.,
RA Blair D., Zhang Q.H., Zhong Y., Wang S., Han Z.G., Chen Z.;
RT "The Schistosoma japonicum genome reveals features of host-parasite
RT interplay.";
RL Nature 460:345-351(2009).
RN [2] {ECO:0000313|EMBL:CAX69783.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Anhui {ECO:0000313|EMBL:CAX69783.1};
RA Gang L.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC {ECO:0000256|ARBA:ARBA00004120}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
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DR EMBL; FN314050; CAX69783.1; -; mRNA.
DR AlphaFoldDB; C1L505; -.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006897; P:endocytosis; IEA:InterPro.
DR CDD; cd15739; FYVE_RABE_unchar; 1.
DR Gene3D; 1.20.5.730; Single helix bin; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR003914; Rabaptin.
DR InterPro; IPR015390; Rabaptin_Rab5-bd_dom.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR31179; RAB GTPASE-BINDING EFFECTOR PROTEIN; 1.
DR PANTHER; PTHR31179:SF6; RAB GTPASE-BINDING EFFECTOR PROTEIN 2; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF09311; Rab5-bind; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 2: Evidence at transcript level;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 662..725
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT COILED 68..102
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 517..632
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 770 AA; 87241 MW; B67CF466909F1FD0 CRC64;
MLSHNLDYKQ SSVRESFLDN TAGNFTRPPL PAFISDILDQ LTDNELKNRL GSAFRDKESE
LLESQSAYKH AQNEVIESKK QLAKLELELA NIKSAAEMLM IEHDDALSCL KKQYDEELSS
LLIASEQGYL HQFVDDEHSN NPTPYSATTE NETCSTPKSS FITVEKKSAQ SLANQAFDKV
ERLIRRVSHH KALTNNFILN KTGVSSFWAN NPEVCSNKEE EQTEDGNDDD DYVRSIVEPY
ETEISRLQQI LVNAAIPFTA TSHPNSLNRK LTDEKIANKI LHDSNTKIDI SGNDDDCNNI
NVVDDGSSLN NFIDRSCDKK TENHSVHESS FSNNDHLDIN ENYENIQPVI VKQSICDHSL
SFEGQSSITD TVEKLEKKLA TVTNELNLKT QALKVSTDRQ LELENALKTQ VSEQISKTEK
ISTLANQLAQ RLDGLLLNYK AYRETTEREI SNLLVERKIA DTNLQIIRSH YDSLVGRRSQ
AAAELSRQPI QLPNEKDELE HLALKLYEEN LSFREARDHL EERLNKESEA HKEQLANEQQ
ERLNFESSAL QELEDARQRL ANLSNIATER DNESILRQKY EEELKSSKSK LNEVQAKYEL
TETSLIEAQK RIVDLQDQIV RLQNDLDNIE SVQADFVRLS QNLQVQLERL RQQDHEVRWI
NPDDVTACFA CNSSFSTGLG SANAKKINCR HCGKVHCSNC MKNSVPAGPF GHPAVVCDVC
HTLLNKNIAP YFSTSLSNNN NPKDQLLSST KRYSLSSPTQ SLTNLTTRPS
//
