ID   C1LA41_SCHJA            Unreviewed;       342 AA.
AC   C1LA41;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Cathepsin B-like cysteine proteinase {ECO:0000313|EMBL:CAX71569.1};
DE            EC=3.4.22.- {ECO:0000313|EMBL:CAX71569.1};
OS   Schistosoma japonicum (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6182 {ECO:0000313|EMBL:CAX71569.1};
RN   [1] {ECO:0000313|EMBL:CAX71569.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Anhui {ECO:0000313|EMBL:CAX71569.1};
RX   DOI=10.1038/nature08140;
RA   Liu F., Zhou Y., Wang Z.Q., Lu G., Zheng H., Brindley P.J., McManus D.P.,
RA   Blair D., Zhang Q.H., Zhong Y., Wang S., Han Z.G., Chen Z.;
RT   "The Schistosoma japonicum genome reveals features of host-parasite
RT   interplay.";
RL   Nature 460:345-351(2009).
RN   [2] {ECO:0000313|EMBL:CAX71569.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Anhui {ECO:0000313|EMBL:CAX71569.1};
RA   Gang L.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase C1 family.
CC       {ECO:0000256|ARBA:ARBA00008455}.
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DR   EMBL; FN315836; CAX71568.1; -; mRNA.
DR   EMBL; FN315837; CAX71569.1; -; mRNA.
DR   AlphaFoldDB; C1LA41; -.
DR   MEROPS; C01.062; -.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd02620; Peptidase_C1A_CathepsinB; 1.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR025661; Pept_asp_AS.
DR   InterPro; IPR025660; Pept_his_AS.
DR   InterPro; IPR013128; Peptidase_C1A.
DR   InterPro; IPR000668; Peptidase_C1A_C.
DR   InterPro; IPR012599; Propeptide_C1A.
DR   PANTHER; PTHR12411:SF1000; CATHEPSIN B1, ISOFORM A; 1.
DR   PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR   Pfam; PF00112; Peptidase_C1; 1.
DR   Pfam; PF08127; Propeptide_C1; 1.
DR   PRINTS; PR00705; PAPAIN.
DR   SMART; SM00645; Pept_C1; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR   PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Hydrolase {ECO:0000313|EMBL:CAX71569.1}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..342
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5007360916"
FT   DOMAIN          90..339
FT                   /note="Peptidase C1A papain C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00645"
SQ   SEQUENCE   342 AA;  38711 MW;  D6F1C3E9913E7E68 CRC64;
     MLKIAVYIVS LFNLLEAHVT TRNNERIEPL SDEMISFINK HPNAGWKADK SDRFHSVDDA
     RILLGGRRED PNLREKRRPT VDHHDLNVEI PSHFDSRKKW PRCKSISQIR DQSQCGSSWA
     VSAVGAMSDR ICIQSGGKQS VELSAVDLIS CCKYCGSGCD GGFLGPSWDY WVLRGIVTGG
     SKENHTGCRP YPFPKCDHFV KGKYRACGDK LYKTPQCKQI CQKGYNTSYE QDKHYGGFSY
     NVLSVESVIQ KDIMMHGPVE AYLEIYEDFL NYKSGIYRYT TGQFISGHAV RLIGWGVENG
     TAYWLAANTW NEDWGEKGYF RIVRGRNECS IESEIAAGLI KS
//