ID C1LH18_SCHJA Unreviewed; 816 AA.
AC C1LH18;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Cullin-3 {ECO:0000313|EMBL:CAX73996.1, ECO:0000313|EMBL:TNN19305.1};
GN Name=CUL3 {ECO:0000313|EMBL:CAX73996.1};
GN ORFNames=EWB00_009039 {ECO:0000313|EMBL:TNN19305.1};
OS Schistosoma japonicum (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6182 {ECO:0000313|EMBL:CAX73996.1};
RN [1] {ECO:0000313|EMBL:CAX73996.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Anhui {ECO:0000313|EMBL:CAX73996.1};
RX DOI=10.1038/nature08140;
RA Liu F., Zhou Y., Wang Z.Q., Lu G., Zheng H., Brindley P.J., McManus D.P.,
RA Blair D., Zhang Q.H., Zhong Y., Wang S., Han Z.G., Chen Z.;
RT "The Schistosoma japonicum genome reveals features of host-parasite
RT interplay.";
RL Nature 460:345-351(2009).
RN [2] {ECO:0000313|EMBL:CAX73996.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Anhui {ECO:0000313|EMBL:CAX73996.1};
RA Gang L.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:TNN19305.1, ECO:0000313|Proteomes:UP000311919}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HuSjv2 {ECO:0000313|EMBL:TNN19305.1};
RC TISSUE=Worms {ECO:0000313|EMBL:TNN19305.1};
RA Hu W., Luo F., Yin M., Mo X., Sun C., Wu Q., Zhu B., Xiang M., Wang J.,
RA Wang Y., Zhang T., Xu B., Zheng H., Feng Z.;
RT "An improved genome assembly of the fluke Schistosoma japonicum.";
RL Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the cullin family.
CC {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC ECO:0000256|RuleBase:RU003829}.
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DR EMBL; FN318267; CAX73996.1; -; mRNA.
DR EMBL; FN318268; CAX73997.1; -; mRNA.
DR EMBL; SKCS01000051; TNN19305.1; -; Genomic_DNA.
DR AlphaFoldDB; C1LH18; -.
DR STRING; 6182.C1LH18; -.
DR Proteomes; UP000311919; Unassembled WGS sequence.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11932; CULLIN; 1.
DR PANTHER; PTHR11932:SF168; CULLIN-3; 1.
DR Pfam; PF00888; Cullin; 2.
DR Pfam; PF10557; Cullin_Nedd8; 1.
DR SMART; SM00182; CULLIN; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000311919}.
FT DOMAIN 383..685
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
SQ SEQUENCE 816 AA; 94046 MW; 227860A08E161A09 CRC64;
MATGSSTRRT EVTSAKVRIK AFPPSIDERY ANQLWDQIKS AIIEIQKKNN SCLSFEELYR
NAYTLILQKH GERLYAGTEA VVREHMIRIR DSIVENLNNK FLTYLNSCWK DHQTAMGMIR
DILMYMDRVY VGPHNLDGVY KMGMTVFCDL VVRYPIIRES LQKTLLDMVR RERRGEVISR
SQIRDACQMF VQLGAGSLRV YLEDFEQPFL EQSREFYRIE SENFLAENTS ASLYIKKVEQ
RIEEEIRRAH HHLDASTEPK IVSVLEEELI SRHMETIVGM EDSGLTYMLT HDHFSDIAAM
YNVLSRVEEG PKIMSNYISL YLREQGRSTV RDTGSSTPQQ HIEDLLRLRD RANELLTRAL
NNQTIFRNQI NSDFEYFVNL NPRSPEFLSL FIDEKLKRGT KGMADQDVDA IFDKCIVLFR
YLQEKDLFEG YYKKHLAKRL LLSKSQSDDQ EKIMISKLMA ECGAVYTSKL EGMFKDMAVS
KTLMDEFNGV LSNGNRNLNL DLYVRVLTTG LWPTQIITST EALPEEADAA FKVYKSFYLS
KHNGRKISLQ TNMGYAELSA VFYGRPNADV NNTSQGCSVA DSHTHGFLIH GCNTGSSNQV
TSQCGQHGLI SGLPGSPGAP KTLDPPNAIS ASSRSNVRKY FLQVSTYQMI ILMKFNRRNR
YSFIELASET NIPERELKRS LMALALGRCS QRILCKEPKT RDIESTDVFY VNDSFVSKHI
KVRVQSITVK ESEPERQETR TKVDENRRYV IEATIVRVMK ARKTLSHGQL VVEVIEQLKS
RFVPTPLMIK QRIESLIERE FLARLEDDRR VYKYLA
//
