ID C1MLE0_MICPC Unreviewed; 1036 AA.
AC C1MLE0;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=beta-galactosidase {ECO:0000256|ARBA:ARBA00012756};
DE EC=3.2.1.23 {ECO:0000256|ARBA:ARBA00012756};
DE AltName: Full=Lactase {ECO:0000256|ARBA:ARBA00032230};
GN ORFNames=MICPUCDRAFT_70834 {ECO:0000313|EMBL:EEH59925.1};
OS Micromonas pusilla (strain CCMP1545) (Picoplanktonic green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Mamiellaceae; Micromonas.
OX NCBI_TaxID=564608 {ECO:0000313|Proteomes:UP000001876};
RN [1] {ECO:0000313|EMBL:EEH59925.1, ECO:0000313|Proteomes:UP000001876}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1545 {ECO:0000313|EMBL:EEH59925.1,
RC ECO:0000313|Proteomes:UP000001876};
RX PubMed=19359590; DOI=10.1126/science.1167222;
RA Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W., Gready J.E.,
RA John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F., Moreau H.,
RA Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I., Piegu B.,
RA Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T., Zelensky A.,
RA Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W., Van de Peer Y.,
RA Grigoriev I.V.;
RT "Green evolution and dynamic adaptations revealed by genomes of the marine
RT picoeukaryotes Micromonas.";
RL Science 324:268-272(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001412};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401}.
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DR EMBL; GG663736; EEH59925.1; -; Genomic_DNA.
DR RefSeq; XP_003056549.1; XM_003056503.1.
DR AlphaFoldDB; C1MLE0; -.
DR STRING; 564608.C1MLE0; -.
DR GeneID; 9682027; -.
DR KEGG; mpp:MICPUCDRAFT_70834; -.
DR eggNOG; KOG2024; Eukaryota.
DR OMA; EITDFCH; -.
DR OrthoDB; 276651at2759; -.
DR Proteomes; UP000001876; Unassembled WGS sequence.
DR GO; GO:0009341; C:beta-galactosidase complex; IEA:InterPro.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 2.70.98.10; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR004199; B-gal_small/dom_5.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR014718; GH-type_carb-bd.
DR InterPro; IPR006101; Glyco_hydro_2.
DR InterPro; IPR023232; Glyco_hydro_2_AS.
DR InterPro; IPR006103; Glyco_hydro_2_cat.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR006104; Glyco_hydro_2_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR032312; LacZ_4.
DR PANTHER; PTHR46323; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR46323:SF2; BETA-GALACTOSIDASE; 1.
DR Pfam; PF02929; Bgal_small_N; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF02836; Glyco_hydro_2_C; 1.
DR Pfam; PF02837; Glyco_hydro_2_N; 1.
DR Pfam; PF16353; LacZ_4; 1.
DR PRINTS; PR00132; GLHYDRLASE2.
DR SMART; SM01038; Bgal_small_N; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 2.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS00608; GLYCOSYL_HYDROL_F2_2; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EEH59925.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001876}.
FT DOMAIN 709..1007
FT /note="Beta galactosidase small chain/"
FT /evidence="ECO:0000259|SMART:SM01038"
SQ SEQUENCE 1036 AA; 115961 MW; B66A7229AC7F2B3E CRC64;
MFYPFPLDPP RARRQNPTGC YRQTFELPVS WISDDRRVFV VFEGVDSAFY CWINGKFVGY
SQDSRLPAEF DVTEYLLPGT NLLAAQVMRW SDGSYLEDQD HWWLSGIHRD VVLYVKEPTF
IADYVVSTNV PEGSVGSALV VADVFVHEAV TADVSLPSDV DLDVQLYDAN RKLVADATTD
SSDLELCDPG EVHGQPFEKS PPYFIRKVSV KLEIPTAHLW TAETPYLYTL VMRTLSPLGR
SIDQNGPKMK VISDVEACRV GVRTVKIFGQ RLRVNQEPII IQGVNRHEHC PKHGKAVTKQ
SMLQDVIMMK RYNFNAVRTS HYPNHPRFYD LCDEHGLYVC DEANMETHGF NVGLHPTPFL
SNDPRWRLAH IARVARMIQR DRNHASIIMW SLGNEAGCGG GQHAMATWAR LNDSTRPLHY
ESGGSRTTCT DIICPMYARV RTCEYMAAET CAQGRPVILC EYSHAMGNSN GNVNKYWDCF
RKEGAVQGGF VWDWVDQGLD SVSHDGQRFW AYGGDFGDQP NDAQFCINGL VFPDRRPHPA
TEELKFLMRP VTFHLTMSSE TTPYSDVDVY VRNWLNFSTL NGLQTSWTIM ADSGTMLSAG
DLSLPVIPAG CVLNFPWLSY FPKLSELALA ALRCYHSSRI APLRELYLEL RTIIQRPTSW
CDGGHEVACT QLTLPMPFGG FLPGPKIMKS LPTKFPTLRV HESSEGLLQV QSAAGMDLTF
YLTGKLNGTV RSAFDRGLPI LVGGPVPCFW RAPTDNDRGG EDISYCSRWR RAGMDRLRMV
SYLFLQVLDS ELVSSPSGSI RMSATYRFNS GGDNCDDTSG ISAELTHVVH TTGSVSVFMT
INASRSLPPL PRVGLQMCSP NSMRRIEWFG RGPNECYPDR KTAAMMGRYV TSVDDMHVPY
IIPGENSGRS DVSWMALRCA TSASNLGKYD AATAATLPEK LHSWTLGPGA VHTHELDVLD
NVKESFVHVH IDHVHMGVGG DDSWTPSVHP EFTIQTGREM TFGITIVALP REGDPFEVYQ
HLQRQGLLQD GYSDCH
//
