ID C1MZI9_MICPC Unreviewed; 743 AA.
AC C1MZI9;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 24-JAN-2024, entry version 60.
DE SubName: Full=DNA mismatch repair and recombination {ECO:0000313|EMBL:EEH54877.1};
GN Name=Mlh1 {ECO:0000313|EMBL:EEH54877.1};
GN ORFNames=MICPUCDRAFT_44648 {ECO:0000313|EMBL:EEH54877.1};
OS Micromonas pusilla (strain CCMP1545) (Picoplanktonic green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Mamiellaceae; Micromonas.
OX NCBI_TaxID=564608 {ECO:0000313|Proteomes:UP000001876};
RN [1] {ECO:0000313|EMBL:EEH54877.1, ECO:0000313|Proteomes:UP000001876}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1545 {ECO:0000313|EMBL:EEH54877.1,
RC ECO:0000313|Proteomes:UP000001876};
RX PubMed=19359590; DOI=10.1126/science.1167222;
RA Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W., Gready J.E.,
RA John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F., Moreau H.,
RA Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I., Piegu B.,
RA Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T., Zelensky A.,
RA Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W., Van de Peer Y.,
RA Grigoriev I.V.;
RT "Green evolution and dynamic adaptations revealed by genomes of the marine
RT picoeukaryotes Micromonas.";
RL Science 324:268-272(2009).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; GG663743; EEH54877.1; -; Genomic_DNA.
DR RefSeq; XP_003061227.1; XM_003061181.1.
DR AlphaFoldDB; C1MZI9; -.
DR STRING; 564608.C1MZI9; -.
DR GeneID; 9686401; -.
DR KEGG; mpp:MICPUCDRAFT_44648; -.
DR eggNOG; KOG1979; Eukaryota.
DR OMA; ANYHVKK; -.
DR OrthoDB; 5475669at2759; -.
DR Proteomes; UP000001876; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR032189; Mlh1_C.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF16413; Mlh1_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001876}.
FT DOMAIN 219..345
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 424..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 743 AA; 79484 MW; 1A8C0484E3177F35 CRC64;
MAPADEPRPI RRLAEDVVNR VAAGEVIHRP SSALKELLEN ALDAGATAIT VTVKDGGCKL
LQVTDDGVGI RENDLAILCE RHTTSKLATF EDLNEVATFG FRGEALASMS FVANLTVTTM
TKDAPHALKA SYRDGVLENG AAMPCAGVKG TTIAVENLFY NVPTRRKALR SPTEEYNRIV
DVVQRYASSR TATSFVIRKL GEARPALHCP VATERVDRLR AVYGAAVAKE LTPLRLNVSM
PGAGAGGLRF ALDALISSSS YHSKKSTFVL FINDRLVECA GLKRAIEAVY AAVLPKAEKP
FVYAALTLPP RAVDVNVHPT KREVHFLHQD ELIDEVQRAV EGVLRGANAS RTFSVGTVVG
GGEGGGGKRA KTGTRDKPAY EPRKLVRTDA RLAAGSMEAF VTRDAAAGAA AGADAAARLD
EARRSARERS FGDVNASAGG APGMELDDEE RALRGEEEEE EIDAARAEAR AEAAAAAAAR
AIPDGQTTEL TSVRELWRDI AASAHEGLTA VVRKLTLVGP ADANKALWLV QHGTKLFLVR
ARRMAREFFY QRAIARFGTH PRRALSSPAP LAEMVRMALE AEKDDGEGAS AGDEAAAANA
VAALLVEKAP MLREYFSVDI DEDAKTLVGL PVLLEGHTPD VTRVPEFILS LAHEVDWKEE
KACFKTVAAA LAEFYGGGGG GDDDDGNGDG DENAAETDDT RAWRLVLFPG MMRHLRPSAA
LATGGGILQV ACLEQLYRVF ERC
//
