ID C2E582_LACJH Unreviewed; 459 AA.
AC C2E582;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=23S rRNA (Uracil-5-)-methyltransferase RumA {ECO:0000313|EMBL:EEJ59957.1};
DE EC=2.1.1.- {ECO:0000313|EMBL:EEJ59957.1};
GN Name=rumA {ECO:0000313|EMBL:EEJ59957.1};
GN ORFNames=HMPREF0528_0906 {ECO:0000313|EMBL:EEJ59957.1};
OS Lactobacillus johnsonii ATCC 33200.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=525330 {ECO:0000313|EMBL:EEJ59957.1, ECO:0000313|Proteomes:UP000003491};
RN [1] {ECO:0000313|EMBL:EEJ59957.1, ECO:0000313|Proteomes:UP000003491}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33200 {ECO:0000313|EMBL:EEJ59957.1,
RC ECO:0000313|Proteomes:UP000003491};
RA Qin X., Bachman B., Battles P., Bell A., Bess C., Bickham C., Chaboub L.,
RA Chen D., Coyle M., Deiros D.R., Dinh H., Forbes L., Fowler G.,
RA Francisco L., Fu Q., Gubbala S., Hale W., Han Y., Hemphill L.,
RA Highlander S.K., Hirani K., Hogues M., Jackson L., Jakkamsetti A.,
RA Javaid M., Jiang H., Korchina V., Kovar C., Lara F., Lee S., Mata R.,
RA Mathew T., Moen C., Morales K., Munidasa M., Nazareth L., Ngo R.,
RA Nguyen L., Okwuonu G., Ongeri F., Patil S., Petrosino J., Pham C., Pham P.,
RA Pu L.-L., Puazo M., Raj R., Reid J., Rouhana J., Saada N., Shang Y.,
RA Simmons D., Thornton R., Warren J., Weissenberger G., Zhang J., Zhang L.,
RA Zhou C., Zhu D., Muzny D., Worley K., Gibbs R.;
RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RNA M5U methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01024}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEJ59957.1}.
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DR EMBL; ACGR01000032; EEJ59957.1; -; Genomic_DNA.
DR RefSeq; WP_004893786.1; NZ_GG670120.1.
DR PATRIC; fig|525330.7.peg.1020; -.
DR HOGENOM; CLU_014689_7_1_9; -.
DR Proteomes; UP000003491; Unassembled WGS sequence.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 2.40.50.1070; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR030390; MeTrfase_TrmA_AS.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR002792; TRAM_dom.
DR InterPro; IPR010280; U5_MeTrfase_fam.
DR NCBIfam; TIGR00479; rumA; 1.
DR PANTHER; PTHR11061:SF45; -; 1.
DR PANTHER; PTHR11061; RNA M5U METHYLTRANSFERASE; 1.
DR Pfam; PF01938; TRAM; 1.
DR Pfam; PF05958; tRNA_U5-meth_tr; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51687; SAM_MT_RNA_M5U; 1.
DR PROSITE; PS50926; TRAM; 1.
DR PROSITE; PS01230; TRMA_1; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01024};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01024};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01024}.
FT ACT_SITE 414
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10015"
FT ACT_SITE 414
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 289
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 318
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 339
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 387
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
SQ SEQUENCE 459 AA; 52284 MW; 71B0E65B4D97DDC9 CRC64;
MTKFTKNKQE KNIIITIKRL GINGEGIGYY KKKIIFIPGA LPNEIVVAKI VDRHPHYLEG
ELVRIKEKSP DRVTFPKGVD PAVGGLELAH LSYPKQLEFK QHLILESLRK YHPRDYIKYK
VKKTIPAPNA WNYRNKAQYQ IEFNKGKSKL GLYAPNSRRL INLPDMPTQT KETQKVEREI
KKLVDKLHIR IADFRRHTYG IKTIAVRQSN ATGEIQVTLI TIGKKIKDLK LLASHIMKLP
NVVSVFQNET QWQNPQVWGN KTIKLFGKSH ITEEILGKKF KLSPRAFFQL NPEQTTTLYS
EALKYLDLTP DQTLIDAYAG VGTLGILASD QVRQVIGIES IPEAVIDAQE NCRLNHVRNA
EYIQGNVEKL LPELKNQGVP INALIVDPPR TGLSKKLIKT LLEVKPETFV YVSCNPATLA
KDLVLLSEAY DVRVIQPVDM MPQTPRWEGV AKLVLRKNK
//