ID C2EHQ5_9LACO Unreviewed; 287 AA.
AC C2EHQ5;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 24-JAN-2024, entry version 59.
DE SubName: Full=Phosphogluconate dehydrogenase (Decarboxylating), NAD binding domain protein {ECO:0000313|EMBL:EEJ73902.1};
DE EC=1.1.1.31 {ECO:0000313|EMBL:EEJ73902.1};
GN Name=mmsB {ECO:0000313|EMBL:EEJ73902.1};
GN ORFNames=HMPREF0545_1177 {ECO:0000313|EMBL:EEJ73902.1};
OS Ligilactobacillus salivarius DSM 20555 = ATCC 11741.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Ligilactobacillus.
OX NCBI_TaxID=1423799 {ECO:0000313|EMBL:EEJ73902.1, ECO:0000313|Proteomes:UP000003531};
RN [1] {ECO:0000313|EMBL:EEJ73902.1, ECO:0000313|Proteomes:UP000003531}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11741 {ECO:0000313|EMBL:EEJ73902.1,
RC ECO:0000313|Proteomes:UP000003531};
RA Qin X., Bachman B., Battles P., Bell A., Bess C., Bickham C., Chaboub L.,
RA Chen D., Coyle M., Deiros D.R., Dinh H., Forbes L., Fowler G.,
RA Francisco L., Fu Q., Gubbala S., Hale W., Han Y., Hemphill L.,
RA Highlander S.K., Hirani K., Hogues M., Jackson L., Jakkamsetti A.,
RA Javaid M., Jiang H., Korchina V., Kovar C., Lara F., Lee S., Mata R.,
RA Mathew T., Moen C., Morales K., Munidasa M., Nazareth L., Ngo R.,
RA Nguyen L., Okwuonu G., Ongeri F., Patil S., Petrosino J., Pham C., Pham P.,
RA Pu L.-L., Puazo M., Raj R., Reid J., Rouhana J., Saada N., Shang Y.,
RA Simmons D., Thornton R., Warren J., Weissenberger G., Zhang J., Zhang L.,
RA Zhou C., Zhu D., Muzny D., Worley K., Gibbs R.;
RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEJ73902.1}.
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DR EMBL; ACGT01000019; EEJ73902.1; -; Genomic_DNA.
DR RefSeq; WP_003701429.1; NZ_GG693226.1.
DR AlphaFoldDB; C2EHQ5; -.
DR GeneID; 69723229; -.
DR PATRIC; fig|1423799.3.peg.1705; -.
DR HOGENOM; CLU_035117_1_0_9; -.
DR Proteomes; UP000003531; Unassembled WGS sequence.
DR GO; GO:0008442; F:3-hydroxyisobutyrate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000313|EMBL:EEJ73902.1}.
FT DOMAIN 2..159
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 165..279
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 171
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 287 AA; 30877 MW; 0F83C5268C004AB2 CRC64;
MKIGFIGTGV MGNAISVNLL KAGYEMVVYN RTKSKTDNLV SLGASWADSP KEVAQQSDII
FTMVGFPPDV EDVYFNSETG IFAGAKPQSI LVDMTTSRPS LAQKIYQEGQ KRNLFVLDAP
VSGGDVGAKN GTLTVMVGGD KESFDKLTDI FEVISQSYHL FGPAGSGQHA KMANQIMIAG
TMTGLTEMLV YAKKAGLDLD SILTTVGAGS AANWSLSNYG PRILASDYTP GFFAKHFLKD
LRIALDSAKD MGIHLPATEK AEELYQTMVD EFKLGNDGTQ GLIKIYD
//
