ID C2ENG4_9LACO Unreviewed; 834 AA.
AC C2ENG4;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=UvrABC system protein A {ECO:0000256|ARBA:ARBA00039316};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000256|ARBA:ARBA00042156};
GN ORFNames=HMPREF0548_1210 {ECO:0000313|EMBL:EEJ71968.1};
OS Lactobacillus ultunensis DSM 16047.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=525365 {ECO:0000313|EMBL:EEJ71968.1, ECO:0000313|Proteomes:UP000005583};
RN [1] {ECO:0000313|EMBL:EEJ71968.1, ECO:0000313|Proteomes:UP000005583}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16047 {ECO:0000313|EMBL:EEJ71968.1,
RC ECO:0000313|Proteomes:UP000005583};
RA Qin X., Bachman B., Battles P., Bell A., Bess C., Bickham C., Chaboub L.,
RA Chen D., Coyle M., Deiros D.R., Dinh H., Forbes L., Fowler G.,
RA Francisco L., Fu Q., Gubbala S., Hale W., Han Y., Hemphill L.,
RA Highlander S.K., Hirani K., Hogues M., Jackson L., Jakkamsetti A.,
RA Javaid M., Jiang H., Korchina V., Kovar C., Lara F., Lee S., Mata R.,
RA Mathew T., Moen C., Morales K., Munidasa M., Nazareth L., Ngo R.,
RA Nguyen L., Okwuonu G., Ongeri F., Patil S., Petrosino J., Pham C., Pham P.,
RA Pu L.-L., Puazo M., Raj R., Reid J., Rouhana J., Saada N., Shang Y.,
RA Simmons D., Thornton R., Warren J., Weissenberger G., Zhang J., Zhang L.,
RA Zhou C., Zhu D., Muzny D., Worley K., Gibbs R.;
RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000256|ARBA:ARBA00038000}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEJ71968.1}.
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DR EMBL; ACGU01000055; EEJ71968.1; -; Genomic_DNA.
DR RefSeq; WP_007125738.1; NZ_GG693253.1.
DR AlphaFoldDB; C2ENG4; -.
DR STRING; 525365.HMPREF0548_1210; -.
DR PATRIC; fig|525365.8.peg.246; -.
DR eggNOG; COG0178; Bacteria.
DR HOGENOM; CLU_001370_2_1_9; -.
DR OrthoDB; 9809851at2; -.
DR Proteomes; UP000005583; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0031072; F:heat shock protein binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd10719; DnaJ_zf; 1.
DR Gene3D; 1.10.8.280; ABC transporter ATPase domain-like; 1.
DR Gene3D; 1.20.1580.10; ABC transporter ATPase like domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR001305; HSP_DnaJ_Cys-rich_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR PANTHER; PTHR43152; UVRABC SYSTEM PROTEIN A; 1.
DR PANTHER; PTHR43152:SF3; UVRABC SYSTEM PROTEIN A; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 503..827
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 834 AA; 91775 MW; FB47458C365F1A48 CRC64;
MALPTKIEVR GARVHNLKNI DVDIPLHKFV AISGLSGSGK SSLAMGILYE EGSRRYLDAL
STYMRRRIKQ GAQADVTSVK HIPSALALRQ RPSVPNERAT VGTTTETFNV LRLIYSRLGS
PVCPNGHRVP ASLDIAEAMS KSGDEMGQIT CPTCGTKFYV PSAEDFAFNS DGACKNCGGT
GKVRQIDEDK LIADENLSIE DGAVASWSLP GRNFMPSVAE HAGVRINIPY KDLTDKEKDF
VLNGPEKKYK MDFLSGTGRV FHDFNALYEN AHQAVLRSAK SSKSERAQKR IAEFFTYSTC
PVCHGTCLRP ELLKQLVNGK NIDQVEHMQL GDLPDFGKKL LASLPDDMHK MASSLINEFL
NNLQPLLDLG LDYLTMARAG NTLSTGELQR IQLARTLRTE TTGVLYVLDE PSIGLHPANV
DGLIKILRKL VAQGNSLVVV DHNVDIIKAA DEIIEIGPGS GEQGGQILAQ GSPAEIEKDS
QSLIAPYLNG QAKLMARETA SAPSSERITF EVDHYFNLHD VKASIPLNQI TAVTGFSGAG
KTSLILDSLV PAIQKQSKKE KLPKQIKQFN SPLHNVVSVD ASPIGKSTRS TVATYTSIMD
NLRKLFARQP LAKEKHYTPS YFSYNNKEGA CPTCGGTGIV TLDIQFLPDM QQTCPTCHGE
RYNPKIKQIK WHDMSIVDIL NLDINEALPV FKRVPKIERE LKLLKEVGLD YLHLGESTPT
LSGGEAQRLK LVTHLSHKQD DTLFVFDEPT IGLHPLDVKV LVKVMQKLLD QGATIITISH
DLNLIVNADY MIDLGPRGGE NGGRIVVEGR PLDLIKKLES LTVHYLADYW NQFK
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