ID C2KI83_LEUMC Unreviewed; 586 AA.
AC C2KI83;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=Septation ring formation regulator EzrA {ECO:0000256|HAMAP-Rule:MF_00728};
GN Name=ezrA {ECO:0000256|HAMAP-Rule:MF_00728,
GN ECO:0000313|EMBL:EEJ43047.1};
GN ORFNames=HMPREF0555_0349 {ECO:0000313|EMBL:EEJ43047.1};
OS Leuconostoc mesenteroides subsp. cremoris ATCC 19254.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Leuconostoc.
OX NCBI_TaxID=586220 {ECO:0000313|EMBL:EEJ43047.1, ECO:0000313|Proteomes:UP000004283};
RN [1] {ECO:0000313|EMBL:EEJ43047.1, ECO:0000313|Proteomes:UP000004283}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19254 {ECO:0000313|EMBL:EEJ43047.1,
RC ECO:0000313|Proteomes:UP000004283};
RA Qin X., Bachman B., Battles P., Bell A., Bess C., Bickham C., Chaboub L.,
RA Chen D., Coyle M., Deiros D.R., Dinh H., Forbes L., Fowler G.,
RA Francisco L., Fu Q., Gubbala S., Hale W., Han Y., Hemphill L.,
RA Highlander S.K., Hirani K., Hogues M., Jackson L., Jakkamsetti A.,
RA Javaid M., Jiang H., Korchina V., Kovar C., Lara F., Lee S., Mata R.,
RA Mathew T., Moen C., Morales K., Munidasa M., Nazareth L., Ngo R.,
RA Nguyen L., Okwuonu G., Ongeri F., Patil S., Petrosino J., Pham C., Pham P.,
RA Pu L.-L., Puazo M., Raj R., Reid J., Rouhana J., Saada N., Shang Y.,
RA Simmons D., Thornton R., Warren J., Weissenberger G., Zhang J., Zhang L.,
RA Zhou C., Zhu D., Muzny D., Worley K., Gibbs R.;
RL Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negative regulator of FtsZ ring formation; modulates the
CC frequency and position of FtsZ ring formation. Inhibits FtsZ ring
CC formation at polar sites. Interacts either with FtsZ or with one of its
CC binding partners to promote depolymerization. {ECO:0000256|HAMAP-
CC Rule:MF_00728}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_00728};
CC Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_00728}.
CC Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}. Note=Colocalized with FtsZ to the
CC nascent septal site. {ECO:0000256|HAMAP-Rule:MF_00728}.
CC -!- SIMILARITY: Belongs to the EzrA family. {ECO:0000256|HAMAP-
CC Rule:MF_00728}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEJ43047.1}.
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DR EMBL; ACKV01000010; EEJ43047.1; -; Genomic_DNA.
DR AlphaFoldDB; C2KI83; -.
DR HOGENOM; CLU_034079_2_0_9; -.
DR Proteomes; UP000004283; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005940; C:septin ring; IEA:InterPro.
DR GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR GO; GO:0000921; P:septin ring assembly; IEA:InterPro.
DR HAMAP; MF_00728; EzrA; 1.
DR InterPro; IPR010379; EzrA.
DR Pfam; PF06160; EzrA; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|HAMAP-Rule:MF_00728};
KW Cell division {ECO:0000256|HAMAP-Rule:MF_00728};
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_00728};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|HAMAP-
KW Rule:MF_00728};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_00728};
KW Septation {ECO:0000256|ARBA:ARBA00023210, ECO:0000256|HAMAP-Rule:MF_00728};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_00728};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_00728}.
FT TOPO_DOM 1..20
FT /note="Extracellular"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
FT TRANSMEM 21..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TOPO_DOM 40..586
FT /note="Cytoplasmic"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
FT COILED 144..171
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
FT COILED 321..355
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
FT COILED 387..414
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
SQ SEQUENCE 586 AA; 68063 MW; 6C6EAF05BC7F128E CRC64;
MLRWKVKIKR LETIHMFNFT VLAIILLLVV IAYLAIFVMQ RTTVKKVSDL RARKDQLESL
KVREELVEGR KLPLTGLSLK NYQKFESSFN DVQNNKFLKI DQQANLVLFE ARGINFIKTR
NELERLQGMV DDTETTIKDV RAGLLDLKKT DEEHREAIND LKKKYEGLRK RLLAENFKFG
PANPALDKFL SQLEADYDEF TELTENGDHA TASDIYEQLA METTQMEKMM ADIPDLFDQL
NIKYVDQLNE LAQGHTKLVE AGYVFPNDSV EQELQAIDSQ RQQVLNLLAD LKLKEVTEQT
GYIEQRIDAM YETMETEVTA RKHVTKNADR LSSDLLRLRE QNQTLSIELD RLGQSFQFNH
KELETRRTLL EQINMAEEQI NHNDDLLEAK EISYSELQIQ QEKLLKQFEE IETQQVDIWD
KISGLEKADR SAEQLGGQYQ KEVETIKHAV ERMNLPGLPV AYLEYFYAVS NELKRLAKSL
NTNLIDMDEV QRQLNIVSAD IDTLKEKTEE IVDQAALTEQ LLQYANRYRA SNERVAAASE
QARMFYERDY NFKQAMDILG SALDSAEPGV YERLVDSYMR RKTPLV
//
