ID C2KUD1_9FIRM Unreviewed; 727 AA.
AC C2KUD1;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE SubName: Full=Thiamine pyrophosphate enzyme, central domain protein {ECO:0000313|EMBL:EEJ52619.1};
GN ORFNames=HMPREF6123_0100 {ECO:0000313|EMBL:EEJ52619.1};
OS Oribacterium sinus F0268.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Oribacterium.
OX NCBI_TaxID=585501 {ECO:0000313|EMBL:EEJ52619.1, ECO:0000313|Proteomes:UP000004121};
RN [1] {ECO:0000313|EMBL:EEJ52619.1, ECO:0000313|Proteomes:UP000004121}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0268 {ECO:0000313|EMBL:EEJ52619.1,
RC ECO:0000313|Proteomes:UP000004121};
RA Qin X., Bachman B., Battles P., Bell A., Bess C., Bickham C., Chaboub L.,
RA Chen D., Coyle M., Deiros D.R., Dinh H., Forbes L., Fowler G.,
RA Francisco L., Fu Q., Gubbala S., Hale W., Han Y., Hemphill L.,
RA Highlander S.K., Hirani K., Hogues M., Jackson L., Jakkamsetti A.,
RA Javaid M., Jiang H., Korchina V., Kovar C., Lara F., Lee S., Mata R.,
RA Mathew T., Moen C., Morales K., Munidasa M., Nazareth L., Ngo R.,
RA Nguyen L., Okwuonu G., Ongeri F., Patil S., Petrosino J., Pham C., Pham P.,
RA Pu L.-L., Puazo M., Raj R., Reid J., Rouhana J., Saada N., Shang Y.,
RA Simmons D., Thornton R., Warren J., Weissenberger G., Zhang J., Zhang L.,
RA Zhou C., Zhu D., Muzny D., Worley K., Gibbs R.;
RL Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEJ52619.1}.
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DR EMBL; ACKX01000013; EEJ52619.1; -; Genomic_DNA.
DR RefSeq; WP_007157635.1; NZ_GG668535.1.
DR AlphaFoldDB; C2KUD1; -.
DR STRING; 585501.HMPREF6123_0100; -.
DR eggNOG; COG0028; Bacteria.
DR HOGENOM; CLU_013748_1_3_9; -.
DR InParanoid; C2KUD1; -.
DR OrthoDB; 4494979at2; -.
DR Proteomes; UP000004121; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR CDD; cd00568; TPP_enzymes; 1.
DR CDD; cd07035; TPP_PYR_POX_like; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR045229; TPP_enz.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR PANTHER; PTHR18968:SF142; ACETOLACTATE SYNTHASE; 1.
DR PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000004121};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 4..116
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 263..399
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 497..678
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 727 AA; 80061 MW; B1F0567A5C059ECD CRC64;
MKIRVADYIA QKCYSMGLSR NFSVVGGGAM HLNDALGHHK GIKTLYQHHE QACAMAAESY
ARIHNVPGIV CVTSGPGGTN AITGVVGAYL DSIPMLVLSG QVRHDNTARW SGRALRAMGD
QEFDILQSVS CMCKYSEMLI DPYRVRYAIE KAIYLCQTGR PGPCWLDVPV DVQGFMVEEE
DLLGFSPESY AAGGDGWADG TVKNSHPETA TALRRYFASD AEKEALLKAL SSEKNPHILE
EDKTEKKEKT GIQNWQDFLP LAKEVLEKIR SSEHPIFYTG NGVRIAGAEG LFLECAEKLG
IPVVLGWNAP DIFPTTHPLN AGRPGGRGDR PGNLAVQNAD VILSIGSRLN IRQVGYSFWE
WAPKACVMQN DIDLEEIAKP SVHCDLPLHG DAKALLEALL HLLKQEEKLP LFAGGKGISR
EKAKGFVRED AAGKILAEKQ DANLTWLDTI RFYQANYPTV LPEYLEERKG ELTNVYALVE
KLSERASEDQ ITVVGNGSPC VAGGQSYIIK KGTRFISQDG VASMGYGLPA AIGAYYGVVD
FTEEEKKRLS EDPYWKGKGE IYPPYQGKDI LLMTGDGSIQ MNLQELQTII HHQMPIKIFV
VNNGGYHSIR QTQNSFFGKP LVGIGVDSGV EGCDLSFPNL EKLAHAYGYP YVSIKENAEL
EQGIEKTLGQ SGPVICEVFV SMEQQFLPKS SAKKDAEGNL FSPPLEDMAP FLPEEEMEML
MLYPRKK
//