ID C2L086_9FIRM Unreviewed; 431 AA.
AC C2L086;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase {ECO:0000313|EMBL:EEJ50564.1};
DE EC=2.5.1.49 {ECO:0000313|EMBL:EEJ50564.1};
GN Name=cysD2 {ECO:0000313|EMBL:EEJ50564.1};
GN ORFNames=HMPREF6123_2155 {ECO:0000313|EMBL:EEJ50564.1};
OS Oribacterium sinus F0268.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Oribacterium.
OX NCBI_TaxID=585501 {ECO:0000313|EMBL:EEJ50564.1, ECO:0000313|Proteomes:UP000004121};
RN [1] {ECO:0000313|EMBL:EEJ50564.1, ECO:0000313|Proteomes:UP000004121}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0268 {ECO:0000313|EMBL:EEJ50564.1,
RC ECO:0000313|Proteomes:UP000004121};
RA Qin X., Bachman B., Battles P., Bell A., Bess C., Bickham C., Chaboub L.,
RA Chen D., Coyle M., Deiros D.R., Dinh H., Forbes L., Fowler G.,
RA Francisco L., Fu Q., Gubbala S., Hale W., Han Y., Hemphill L.,
RA Highlander S.K., Hirani K., Hogues M., Jackson L., Jakkamsetti A.,
RA Javaid M., Jiang H., Korchina V., Kovar C., Lara F., Lee S., Mata R.,
RA Mathew T., Moen C., Morales K., Munidasa M., Nazareth L., Ngo R.,
RA Nguyen L., Okwuonu G., Ongeri F., Patil S., Petrosino J., Pham C., Pham P.,
RA Pu L.-L., Puazo M., Raj R., Reid J., Rouhana J., Saada N., Shang Y.,
RA Simmons D., Thornton R., Warren J., Weissenberger G., Zhang J., Zhang L.,
RA Zhou C., Zhu D., Muzny D., Worley K., Gibbs R.;
RL Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEJ50564.1}.
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DR EMBL; ACKX01000205; EEJ50564.1; -; Genomic_DNA.
DR AlphaFoldDB; C2L086; -.
DR STRING; 585501.HMPREF6123_2155; -.
DR eggNOG; COG2873; Bacteria.
DR HOGENOM; CLU_018986_4_2_9; -.
DR InParanoid; C2L086; -.
DR Proteomes; UP000004121; Unassembled WGS sequence.
DR GO; GO:0003961; F:O-acetylhomoserine aminocarboxypropyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR006235; OAc-hSer/O-AcSer_sulfhydrylase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR NCBIfam; TIGR01326; OAH_OAS_sulfhy; 1.
DR PANTHER; PTHR43797; HOMOCYSTEINE/CYSTEINE SYNTHASE; 1.
DR PANTHER; PTHR43797:SF3; O-ACETYLHOMOSERINE SULFHYDRYLASE; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR001434-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000004121};
KW Transferase {ECO:0000313|EMBL:EEJ50564.1}.
FT MOD_RES 213
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ SEQUENCE 431 AA; 47102 MW; 6EA51D4C365D30BA CRC64;
MKGVLIMANY NIDTICVQGG YEPKKGEPRV VPIVQSTTFK YETSRQMGDL FDLKEPGYFY
TRLANPTNDA VANKICQLEG GVAAILTSSG QAANFYAIFN IAGAGDHVIA SSAIYGGTYN
LIAKTMKNMG IETTFVDPDI SPEELDSKFR PNTKLVFGEV LANPALKILD IEKFAKVAHQ
HGVPLIVDNT FPTPIFCRPF EWGADIVTHS TTKYMNGFAN SVGGAVVDSG NFDWTKYSEK
FPGLTTPDET YHGTVYTESF GKAAYIVKMT TNLMRDLGSI PSPQNSFYLG VGLETLHLRM
ERHYENALAL AKHLEKHPKV SWVSFSGLEN DSQHELAKKY LPKGSCGVIS FGVVGGREAA
VKFMDSLKLA AIVTHVADAR TCVLHPASTT HRQMNDEELL AAGVSPDLIR MSVGIEDVQD
IIADVDQALE K
//
