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Database: UniProt
Entry: C2UHU5_BACCE
LinkDB: C2UHU5_BACCE
Original site: C2UHU5_BACCE 
ID   C2UHU5_BACCE            Unreviewed;       259 AA.
AC   C2UHU5;
DT   16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT   16-JUN-2009, sequence version 1.
DT   19-FEB-2014, entry version 27.
DE   RecName: Full=GTP-sensing transcriptional pleiotropic repressor CodY;
GN   Name=codY; ORFNames=bcere0018_35450;
OS   Bacillus cereus Rock1-15.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=526982;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Rock1-15;
RX   PubMed=22645259; DOI=10.1101/gr.134437.111;
RA   Zwick M.E., Joseph S.J., Didelot X., Chen P.E., Bishop-Lilly K.A.,
RA   Stewart A.C., Willner K., Nolan N., Lentz S., Thomason M.K.,
RA   Sozhamannan S., Mateczun A.J., Du L., Read T.D.;
RT   "Genomic characterization of the Bacillus cereus sensu lato species:
RT   Backdrop to the evolution of Bacillus anthracis.";
RL   Genome Res. 22:1512-1524(2012).
CC   -!- FUNCTION: DNA-binding protein that represses the expression of
CC       many genes that are induced as cells make the transition from
CC       rapid exponential growth to stationary phase. It is a GTP-binding
CC       protein that senses the intracellular GTP concentration as an
CC       indicator of nutritional limitations. At low GTP concentration it
CC       no longer binds GTP and stop to act as a transcriptional repressor
CC       (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the CodY family.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data.
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DR   EMBL; ACMH01000086; EEL27366.1; -; Genomic_DNA.
DR   ProteinModelPortal; C2UHU5; -.
DR   SMR; C2UHU5; 1-160, 168-257.
DR   EnsemblBacteria; EEL27366; EEL27366; bcere0018_35450.
DR   PATRIC; 25019222; VBIBacCer37058_5001.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_00621; HTH_type_CodY; 1.
DR   InterPro; IPR014154; GTP_sensing_CodY.
DR   InterPro; IPR010312; GTP_sensing_CodY_N.
DR   InterPro; IPR013198; GTP_sensing_HTH_CodY_C.
DR   InterPro; IPR011991; WHTH_DNA-bd_dom.
DR   Pfam; PF06018; CodY; 1.
DR   Pfam; PF08222; HTH_CodY; 1.
DR   PIRSF; PIRSF011572; GTP_sensing_CodY; 1.
DR   TIGRFAMs; TIGR02787; codY_Gpos; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; DNA-binding; GTP-binding;
KW   Nucleotide-binding; Phosphoprotein; Repressor; Transcription;
KW   Transcription regulation.
FT   DNA_BIND    202    221       H-T-H motif (By similarity).
FT   MOD_RES     215    215       Phosphoserine (By similarity).
SQ   SEQUENCE   259 AA;  28793 MW;  5ACD5C6E90C31A73 CRC64;
     MELLAKTRKL NALLQSAAGK PVNFREMSDT MCEVIEANVF VVSRRGKLLG YAIHQQIENE
     RMKQMLAERQ FPEEYTQSLF NITETSSNLD VNSAYTAFPV ENRELFGQGL TTIVPIVGGG
     ERLGTLVLAR LGQEFLDDDL ILAEYSSTVV GMEILREKAE EIEEEARSKA VVQMAISSLS
     YSELEAIEHI FEELNGTEGL LVASKIADRV GITRSVIVNA LRKLESAGVI ESRSLGMKGT
     YIKVLNDKFL QELAKLKTN
//
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