ID C2UHU5_BACCE Unreviewed; 259 AA.
AC C2UHU5;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 01-MAY-2013, entry version 24.
DE RecName: Full=GTP-sensing transcriptional pleiotropic repressor CodY;
GN Name=codY; ORFNames=bcere0018_35450;
OS Bacillus cereus Rock1-15.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=526982;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Rock1-15;
RX PubMed=22645259; DOI=10.1101/gr.134437.111;
RA Zwick M.E., Joseph S.J., Didelot X., Chen P.E., Bishop-Lilly K.A.,
RA Stewart A.C., Willner K., Nolan N., Lentz S., Thomason M.K.,
RA Sozhamannan S., Mateczun A.J., Du L., Read T.D.;
RT "Genomic characterization of the Bacillus cereus sensu lato species:
RT Backdrop to the evolution of Bacillus anthracis.";
RL Genome Res. 22:1512-1524(2012).
CC -!- FUNCTION: DNA-binding protein that represses the expression of
CC many genes that are induced as cells make the transition from
CC rapid exponential growth to stationary phase. It is a GTP-binding
CC protein that senses the intracellular GTP concentration as an
CC indicator of nutritional limitations. At low GTP concentration it
CC no longer binds GTP and stop to act as a transcriptional repressor
CC (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the CodY family.
CC -!- CAUTION: The sequence shown here is derived from an
CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC preliminary data.
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DR EMBL; ACMH01000086; EEL27366.1; -; Genomic_DNA.
DR ProteinModelPortal; C2UHU5; -.
DR SMR; C2UHU5; 1-160, 168-257.
DR EnsemblBacteria; EEL27366; EEL27366; bcere0018_35450.
DR PATRIC; 25019222; VBIBacCer37058_5001.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:HAMAP.
DR GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:HAMAP.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_00621; HTH_type_CodY; 1; -.
DR InterPro; IPR014154; GTP_sensing_CodY.
DR InterPro; IPR010312; GTP_sensing_CodY_N.
DR InterPro; IPR013198; GTP_sensing_HTH_CodY_C.
DR InterPro; IPR011991; WHTH_DNA-bd_dom.
DR Pfam; PF06018; CodY; 1.
DR Pfam; PF08222; HTH_CodY; 1.
DR PIRSF; PIRSF011572; GTP_sensing_CodY; 1.
DR TIGRFAMs; TIGR02787; codY_Gpos; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; GTP-binding; Nucleotide-binding;
KW Phosphoprotein; Repressor; Transcription; Transcription regulation.
FT DNA_BIND 202 221 H-T-H motif (By similarity).
FT MOD_RES 215 215 Phosphoserine (By similarity).
SQ SEQUENCE 259 AA; 28793 MW; 5ACD5C6E90C31A73 CRC64;
MELLAKTRKL NALLQSAAGK PVNFREMSDT MCEVIEANVF VVSRRGKLLG YAIHQQIENE
RMKQMLAERQ FPEEYTQSLF NITETSSNLD VNSAYTAFPV ENRELFGQGL TTIVPIVGGG
ERLGTLVLAR LGQEFLDDDL ILAEYSSTVV GMEILREKAE EIEEEARSKA VVQMAISSLS
YSELEAIEHI FEELNGTEGL LVASKIADRV GITRSVIVNA LRKLESAGVI ESRSLGMKGT
YIKVLNDKFL QELAKLKTN
//
