ID C3LSG0_VIBCM Unreviewed; 674 AA.
AC C3LSG0;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=General secretion pathway protein D {ECO:0000313|EMBL:ACP06947.1};
GN Name=gspD {ECO:0000313|EMBL:ACP06947.1};
GN OrderedLocusNames=VCM66_2653 {ECO:0000313|EMBL:ACP06947.1};
OS Vibrio cholerae serotype O1 (strain M66-2).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=579112 {ECO:0000313|EMBL:ACP06947.1, ECO:0000313|Proteomes:UP000001217};
RN [1] {ECO:0000313|EMBL:ACP06947.1, ECO:0000313|Proteomes:UP000001217}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M66-2 {ECO:0000313|EMBL:ACP06947.1,
RC ECO:0000313|Proteomes:UP000001217};
RX PubMed=19115014; DOI=10.1371/journal.pone.0004053;
RA Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J.,
RA Wang W., Wang J., Qian W., Li D., Wang L.;
RT "A recalibrated molecular clock and independent origins for the cholera
RT pandemic clones.";
RL PLoS ONE 3:E4053-E4053(2008).
CC -!- SUBCELLULAR LOCATION: Cell outer membrane
CC {ECO:0000256|ARBA:ARBA00004442, ECO:0000256|RuleBase:RU004004}.
CC Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the bacterial secretin family. GSP D subfamily.
CC {ECO:0000256|ARBA:ARBA00006980}.
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DR EMBL; CP001233; ACP06947.1; -; Genomic_DNA.
DR RefSeq; WP_000878557.1; NC_012578.1.
DR AlphaFoldDB; C3LSG0; -.
DR SMR; C3LSG0; -.
DR GeneID; 69718672; -.
DR KEGG; vcm:VCM66_2653; -.
DR HOGENOM; CLU_006756_1_1_6; -.
DR Proteomes; UP000001217; Chromosome I.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015627; C:type II protein secretion system complex; IEA:InterPro.
DR GO; GO:0015628; P:protein secretion by the type II secretion system; IEA:InterPro.
DR Gene3D; 3.30.1370.120; -; 3.
DR InterPro; IPR049371; GspD-like_N0.
DR InterPro; IPR001775; GspD/PilQ.
DR InterPro; IPR005644; NolW-like.
DR InterPro; IPR038591; NolW-like_sf.
DR InterPro; IPR004846; T2SS/T3SS_dom.
DR InterPro; IPR013356; T2SS_GspD.
DR InterPro; IPR004845; T2SS_GspD_CS.
DR NCBIfam; TIGR02517; type_II_gspD; 1.
DR PANTHER; PTHR30332; PROBABLE GENERAL SECRETION PATHWAY PROTEIN D; 1.
DR PANTHER; PTHR30332:SF27; SECRETIN GSPD-RELATED; 1.
DR Pfam; PF00263; Secretin; 1.
DR Pfam; PF03958; Secretin_N; 3.
DR Pfam; PF21305; type_II_gspD_N0; 1.
DR PRINTS; PR00811; BCTERIALGSPD.
DR PRINTS; PR01032; PHAGEIV.
DR PROSITE; PS00875; T2SP_D; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane beta strand {ECO:0000256|ARBA:ARBA00022452};
KW Transport {ECO:0000256|RuleBase:RU004004}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..674
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002927612"
FT DOMAIN 30..99
FT /note="GspD-like N0"
FT /evidence="ECO:0000259|Pfam:PF21305"
FT DOMAIN 126..188
FT /note="NolW-like"
FT /evidence="ECO:0000259|Pfam:PF03958"
FT DOMAIN 192..259
FT /note="NolW-like"
FT /evidence="ECO:0000259|Pfam:PF03958"
FT DOMAIN 267..343
FT /note="NolW-like"
FT /evidence="ECO:0000259|Pfam:PF03958"
FT DOMAIN 450..611
FT /note="Type II/III secretion system secretin-like"
FT /evidence="ECO:0000259|Pfam:PF00263"
FT COILED 246..293
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 674 AA; 73470 MW; 3D77B891A59E6223 CRC64;
MKYWLKKSSW LLAGSLLSTP LAMANEFSAS FKGTDIQEFI NIVGRNLEKT IIVDPSVRGK
VDVRSFDTLN EEQYYSFFLS VLEVYGFAVV EMDNGVLKVI KSKDAKTSAI PVLSGEERAN
GDEVITQVVA VKNVSVRELS PLLRQLIDNA GAGNVVHYDP ANIILITGRA AVVNRLAEII
RRVDQAGDKE IEVVELNNAS AAEMVRIVEA LNKTTDAQNT PEFLKPKFVA DERTNSILIS
GDPKVRERLK RLIKQLDVEM AAKGNNRVVY LKYAKAEDLV EVLKGVSENL QAEKGTGQPT
TSKRNEVMIA AHADTNSLVL TAPQDIMNAM LEVIGQLDIR RAQVLIEALI VEMAEGDGIN
LGVQWGSLES GSVIQYGNTG ASIGNVMIGL EEAKDTTQTK AVYDTNNNFL RNETTTTKGD
YTKLASALSS IQGAAVSIAM GDWTALINAV SNDSSSNILS SPSITVMDNG EASFIVGEEV
PVITGSTAGS NNDNPFQTVD RKEVGIKLKV VPQINEGNSV QLNIEQEVSN VLGANGAVDV
RFAKRQLNTS VMVQDGQMLV LGGLIDERAL ESESKVPLLG DIPLLGQLFR STSSQVEKKN
LMVFIKPTII RDGVTADGIT QRKYNYIRAE QLFRAEKGLR LLDDASVPVL PKFGDDRRHS
PEIQAFIEQM EAKQ
//
