ID C3MEZ8_SINFN Unreviewed; 933 AA.
AC C3MEZ8;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096,
GN ECO:0000313|EMBL:ACP23835.1};
GN OrderedLocusNames=NGR_c00310 {ECO:0000313|EMBL:ACP23835.1};
OS Sinorhizobium fredii (strain NBRC 101917 / NGR234).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX NCBI_TaxID=394 {ECO:0000313|EMBL:ACP23835.1, ECO:0000313|Proteomes:UP000001054};
RN [1] {ECO:0000313|EMBL:ACP23835.1, ECO:0000313|Proteomes:UP000001054}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 101917 / NGR234 {ECO:0000313|Proteomes:UP000001054};
RX PubMed=19376903; DOI=10.1128/AEM.00515-09;
RA Schmeisser C., Liesegang H., Krysciak D., Bakkou N., Le Quere A.,
RA Wollherr A., Heinemeyer I., Morgenstern B., Pommerening-Roeser A.,
RA Flores M., Palacios R., Brenner S., Gottschalk G., Schmitz R.A.,
RA Broughton W.J., Perret X., Strittmatter A.W., Streit W.R.;
RT "Rhizobium sp. strain NGR234 possesses a remarkable number of secretion
RT systems.";
RL Appl. Environ. Microbiol. 75:4035-4045(2009).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; CP001389; ACP23835.1; -; Genomic_DNA.
DR RefSeq; YP_002824588.1; NC_012587.1.
DR AlphaFoldDB; C3MEZ8; -.
DR STRING; 394.NGR_c00310; -.
DR KEGG; rhi:NGR_c00310; -.
DR PATRIC; fig|394.7.peg.2821; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_0_5; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000001054; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000001054}.
FT DOMAIN 757..773
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT COILED 559..586
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 683..690
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 933 AA; 100873 MW; F7D49116F857D705 CRC64;
MSSINACGYC DISFFGTIMN FVSDASSRTG DVLSVSDLAS EESRSTATPM MEQFIEIKAN
NPDSLLFYRM GDFYELFFQD AVEASRALGI TLTKRGQHLG QDIPMCGVPV HAADDYLQKL
IALGFRVAVC EQVEDPAEAK KRGSKSVVRR DVVRLVTPGT ITEDKLLSPS ESNYLMALAR
IRSGSEPAYA LAWIDISTGI FRLAETAESR LLADILRVEP RELILPDTVF HDPELRPVFD
VLGRVAVPQP AVLFDSATAE GRIARYYGVK TLDGFGTFSR AELAAASAAI SYVEKTQIQE
RPALGIPERE SAASTLFIDP ATRANLELVK TLSGAREGTL LRALDRTVTS GGARLLAERL
MSPLTDPDRI NQRLDSIEVL LDQPSFAIDV RDTLRRAPDM PRALSRLALG RGGPRDLGAI
QAGLRAAAAT ATLLSGARLS EELTEAHAAI AALPAALLAR LDSMLAEDLP LLKRDGGFLR
EAASGELDEM RALRDQSRRV IAGLQLQYCE ETGIKSLKIK HNNVLGYFIE VTAGNAGAMT
DTDAGRARFI HRQTMASAMR FTTTELAELE TKIANAADRA LAIELEAFEA MAREVVADAE
AIKAASLALA MLDVSAGLAV LAEEQNYARP AVDRSRMFLI DGGRHPVVEQ ALRRQAGNPF
VANGCDLSPP DGPEAGAIWL LTGPNMGGKS TFLRQNALIA IMAQMGSFVP ANAAHIGIVD
RLFSRVGASD DLARGRSTFM VEMVETAAIL NQATDHSLVI LDEIGRGTAT FDGLSIAWAA
VEHLHEVNRC RGLFATHFHE LTVLSEKLGR LSNATMRVKE WDGDVIFLHE VGPGAADRSY
GIQVARLAGL PASVVARARD VLANLEDADR KNPASQLIDD LPLFQVAVRR EEVARASGPS
RAEEALRAIN PDDMTPREAL EALYALKKDL AGR
//
