ID C3MPX4_SULIL Unreviewed; 350 AA.
AC C3MPX4;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Aspartate-semialdehyde dehydrogenase {ECO:0000313|EMBL:ACP35437.1};
DE EC=1.2.1.11 {ECO:0000313|EMBL:ACP35437.1};
GN OrderedLocusNames=LS215_1429 {ECO:0000313|EMBL:ACP35437.1};
OS Sulfolobus islandicus (strain L.S.2.15 / Lassen #1).
OC Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Sulfolobus.
OX NCBI_TaxID=429572 {ECO:0000313|EMBL:ACP35437.1, ECO:0000313|Proteomes:UP000001747};
RN [1] {ECO:0000313|EMBL:ACP35437.1, ECO:0000313|Proteomes:UP000001747}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=L.S.2.15 / Lassen #1 {ECO:0000313|Proteomes:UP000001747};
RX PubMed=19435847; DOI=10.1073/pnas.0808945106;
RA Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J.;
RT "Biogeography of the Sulfolobus islandicus pan-genome.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009).
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DR EMBL; CP001399; ACP35437.1; -; Genomic_DNA.
DR RefSeq; WP_012713686.1; NC_012589.1.
DR AlphaFoldDB; C3MPX4; -.
DR GeneID; 7797947; -.
DR KEGG; sis:LS215_1429; -.
DR HOGENOM; CLU_049966_1_0_2; -.
DR OrthoDB; 38238at2157; -.
DR Proteomes; UP000001747; Chromosome.
DR GO; GO:0004073; F:aspartate-semialdehyde dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0008652; P:amino acid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR005676; Asp_semi-ald_DH_pep-lack.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR000534; Semialdehyde_DH_NAD-bd.
DR InterPro; IPR012280; Semialdhyde_DH_dimer_dom.
DR NCBIfam; TIGR00978; asd_EA; 1.
DR PANTHER; PTHR46718; ASPARTATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR46718:SF1; ASPARTATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR Pfam; PF01118; Semialdhyde_dh; 1.
DR Pfam; PF02774; Semialdhyde_dhC; 1.
DR PIRSF; PIRSF000148; ASA_dh; 1.
DR SMART; SM00859; Semialdhyde_dh; 1.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:ACP35437.1}.
FT DOMAIN 6..132
FT /note="Semialdehyde dehydrogenase NAD-binding"
FT /evidence="ECO:0000259|SMART:SM00859"
FT ACT_SITE 151
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000148-1"
FT ACT_SITE 244
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000148-1"
SQ SEQUENCE 350 AA; 38790 MW; F75E45C26401DD48 CRC64;
MADKIKVSLL GSTGMVGQKM VRMLSKHPYI ELVKVSASPQ KIGKKYKESV KWIEPGDIPE
NIAELPIVST EYEDHKDVDV VLSALPNELA EDVELKLVKQ GKIVVSNASP FRMDPDVPLI
NPEVNWEHLE LLKYQKSNKN WNGLLVKNPN CTAAILSMPI KPLERLIKIN AMYIVTLQAV
SGAGYSGLPF MAIDGNVVPW IKGEEEKIPK EINKMLGKFE AGKLKSSSLE IHPTTTRVPV
KVGHMGVINI VTNDNVDEKE VQKALDGFAS LPQHKNLPTA PKKPIILFKD EDRPQPARDL
QYYDGMAVTV GRVKFEGNVL RLVVLGDNLV RGAAGITILT LEVMKELGYF
//
