ID   C3MQC6_SULIL            Unreviewed;       445 AA.
AC   C3MQC6;
DT   16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT   16-JUN-2009, sequence version 1.
DT   27-MAR-2024, entry version 58.
DE   SubName: Full=Peptidase U62 modulator of DNA gyrase {ECO:0000313|EMBL:ACP35589.1};
GN   OrderedLocusNames=LS215_1584 {ECO:0000313|EMBL:ACP35589.1};
OS   Sulfolobus islandicus (strain L.S.2.15 / Lassen #1).
OC   Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Sulfolobus.
OX   NCBI_TaxID=429572 {ECO:0000313|EMBL:ACP35589.1, ECO:0000313|Proteomes:UP000001747};
RN   [1] {ECO:0000313|EMBL:ACP35589.1, ECO:0000313|Proteomes:UP000001747}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=L.S.2.15 / Lassen #1 {ECO:0000313|Proteomes:UP000001747};
RX   PubMed=19435847; DOI=10.1073/pnas.0808945106;
RA   Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J.;
RT   "Biogeography of the Sulfolobus islandicus pan-genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009).
CC   -!- SIMILARITY: Belongs to the peptidase U62 family.
CC       {ECO:0000256|ARBA:ARBA00005836}.
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DR   EMBL; CP001399; ACP35589.1; -; Genomic_DNA.
DR   RefSeq; WP_012713772.1; NC_012589.1.
DR   AlphaFoldDB; C3MQC6; -.
DR   GeneID; 8761512; -.
DR   KEGG; sis:LS215_1584; -.
DR   HOGENOM; CLU_026425_1_2_2; -.
DR   OrthoDB; 98233at2157; -.
DR   Proteomes; UP000001747; Chromosome.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.2290.10; PmbA/TldD superfamily; 1.
DR   InterPro; IPR045569; Metalloprtase-TldD/E_C.
DR   InterPro; IPR045570; Metalloprtase-TldD/E_cen_dom.
DR   InterPro; IPR002510; Metalloprtase-TldD/E_N.
DR   InterPro; IPR025502; TldD.
DR   InterPro; IPR035068; TldD/PmbA_N.
DR   InterPro; IPR036059; TldD/PmbA_sf.
DR   NCBIfam; NF040952; Arch_mtprotase_TldD; 1.
DR   PANTHER; PTHR30624:SF0; METALLOPROTEASE SLR0863; 1.
DR   PANTHER; PTHR30624; UNCHARACTERIZED PROTEIN TLDD AND PMBA; 1.
DR   Pfam; PF01523; PmbA_TldD_1st; 1.
DR   Pfam; PF19290; PmbA_TldD_2nd; 1.
DR   Pfam; PF19289; PmbA_TldD_3rd; 1.
DR   PIRSF; PIRSF004919; TldD; 1.
DR   SUPFAM; SSF111283; Putative modulator of DNA gyrase, PmbA/TldD; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Protease {ECO:0000256|ARBA:ARBA00022670}.
FT   DOMAIN          17..76
FT                   /note="Metalloprotease TldD/E N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01523"
FT   DOMAIN          102..204
FT                   /note="Metalloprotease TldD/E central"
FT                   /evidence="ECO:0000259|Pfam:PF19290"
FT   DOMAIN          213..442
FT                   /note="Metalloprotease TldD/E C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19289"
SQ   SEQUENCE   445 AA;  50172 MW;  7A851F5A5DE6BCAE CRC64;
     MMFKYIKRGE ELGASFVDIR YEKTASNEFT ITDDRKYVTS GNDEGYSIRI LYNRNWGFKV
     SDRIDNSTIE EAVNSAFGDE RVNIVYLPSK HDTIKIGKEV NKSKEEMSED LNKIAKQIAN
     LHPSIRSYNL NYYDETIHKE YYSSEDREII LDENISSLNI YVIAREGDTI VDTAENLTTH
     MGYVVDVFDI NEVLEKLSRR IENQLRGKTP KAGEYPVVLA PEVVGVFLHE AIGHLSEADV
     AISGILYELR GKKIGEDFLN ISDVPSIDNP NSTIVYYDDE GVEGREVKII EKGVLKEFMT
     NRYYSAYLGE PPTGNGRTQS YNDFPLPRMR NVYMKPGNNT LSELFEGIKE GYYLGSAIGG
     ETSSDGTFQF AIQEGYRIEN GEIKEPVRNI GFSGNTLTTL SMIDMISKDF GMSAGYCEKN
     GQEVNVSEGG PHVRIKSLKV GGYVR
//