ID C3MWJ0_SULIM Unreviewed; 344 AA.
AC C3MWJ0;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Alcohol dehydrogenase GroES domain protein {ECO:0000313|EMBL:ACP37648.1};
GN OrderedLocusNames=M1425_0848 {ECO:0000313|EMBL:ACP37648.1};
OS Sulfolobus islandicus (strain M.14.25 / Kamchatka #1).
OC Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Sulfolobus.
OX NCBI_TaxID=427317 {ECO:0000313|EMBL:ACP37648.1, ECO:0000313|Proteomes:UP000001350};
RN [1] {ECO:0000313|EMBL:ACP37648.1, ECO:0000313|Proteomes:UP000001350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M.14.25 / Kamchatka #1 {ECO:0000313|Proteomes:UP000001350};
RX PubMed=19435847; DOI=10.1073/pnas.0808945106;
RA Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J.;
RT "Biogeography of the Sulfolobus islandicus pan-genome.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
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DR EMBL; CP001400; ACP37648.1; -; Genomic_DNA.
DR RefSeq; WP_012710917.1; NC_012588.1.
DR AlphaFoldDB; C3MWJ0; -.
DR GeneID; 84052549; -.
DR KEGG; sia:M1425_0848; -.
DR HOGENOM; CLU_026673_11_2_2; -.
DR Proteomes; UP000001350; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd05284; arabinose_DH_like; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR42940; ALCOHOL DEHYDROGENASE 1-RELATED; 1.
DR PANTHER; PTHR42940:SF8; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 10..342
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 344 AA; 37438 MW; B8A802397F6DC804 CRC64;
MKAMKIVEFG KPLELSEVGE ITKTKSNQVL IRVQAAGVCH TDVSVRSGVI YKRISANPPR
LPLTPGHEIA GIVEEVGDEV TGFTKGDKVL INPWQGEGNC FYCKIGEDQY CDSPTWLGIT
TDGGFQEYVL SNHNYVYKIR NLSPYEAAPL ACAGVTSYRA SKLARLNPSS YVAIIGAGGG
LGSIGVQIIR ALYGSIIIAI DVNDEGLELA SKFGADYTLN SRKEVYQEVL KITNGRGVDA
IIDFVGSENT IKSYYTFLAK LGRYIKVGTF GGGLPNEAGL KIHSMGWQFI GTLTGNRKEF
LEVISLAENG RIKPVVTKLR LEEANEALNN LERNKVTGRQ VLIP
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