ID C3N467_SULIA Unreviewed; 400 AA.
AC C3N467;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=glucarate dehydratase {ECO:0000256|ARBA:ARBA00011973};
DE EC=4.2.1.40 {ECO:0000256|ARBA:ARBA00011973};
GN OrderedLocusNames=M1627_0863 {ECO:0000313|EMBL:ACP54799.1};
OS Sulfolobus islandicus (strain M.16.27).
OC Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Sulfolobus.
OX NCBI_TaxID=427318 {ECO:0000313|EMBL:ACP54799.1, ECO:0000313|Proteomes:UP000002307};
RN [1] {ECO:0000313|EMBL:ACP54799.1, ECO:0000313|Proteomes:UP000002307}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M.16.27 {ECO:0000313|EMBL:ACP54799.1,
RC ECO:0000313|Proteomes:UP000002307};
RX PubMed=19435847; DOI=10.1073/pnas.0808945106;
RA Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J.;
RT "Biogeography of the Sulfolobus islandicus pan-genome.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O;
CC Xref=Rhea:RHEA:14573, ChEBI:CHEBI:15377, ChEBI:CHEBI:30612,
CC ChEBI:CHEBI:42819; EC=4.2.1.40;
CC Evidence={ECO:0000256|ARBA:ARBA00001426};
CC -!- PATHWAY: Carbohydrate acid metabolism; D-glucarate degradation; 2,5-
CC dioxopentanoate from D-glucarate: step 1/2.
CC {ECO:0000256|ARBA:ARBA00005183}.
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DR EMBL; CP001401; ACP54799.1; -; Genomic_DNA.
DR RefSeq; WP_012718611.1; NC_012632.1.
DR AlphaFoldDB; C3N467; -.
DR GeneID; 84055448; -.
DR KEGG; sim:M1627_0863; -.
DR HOGENOM; CLU_030273_3_1_2; -.
DR Proteomes; UP000002307; Chromosome.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.120; Enolase-like C-terminal domain; 1.
DR Gene3D; 3.30.390.10; Enolase-like, N-terminal domain; 1.
DR InterPro; IPR034593; DgoD-like.
DR InterPro; IPR036849; Enolase-like_C_sf.
DR InterPro; IPR029017; Enolase-like_N.
DR InterPro; IPR029065; Enolase_C-like.
DR InterPro; IPR013342; Mandelate_racemase_C.
DR InterPro; IPR013341; Mandelate_racemase_N_dom.
DR PANTHER; PTHR48080; D-GALACTONATE DEHYDRATASE-RELATED; 1.
DR PANTHER; PTHR48080:SF4; GLUCARATE DEHYDRATASE; 1.
DR Pfam; PF13378; MR_MLE_C; 1.
DR Pfam; PF02746; MR_MLE_N; 1.
DR SFLD; SFLDS00001; Enolase; 1.
DR SFLD; SFLDG00055; glucarate_dehydratase; 1.
DR SMART; SM00922; MR_MLE; 1.
DR SUPFAM; SSF51604; Enolase C-terminal domain-like; 1.
DR SUPFAM; SSF54826; Enolase N-terminal domain-like; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 144..239
FT /note="Mandelate racemase/muconate lactonizing enzyme C-
FT terminal"
FT /evidence="ECO:0000259|SMART:SM00922"
SQ SEQUENCE 400 AA; 44876 MW; F0808F531BA35983 CRC64;
MKIKNLETKT IAIPLKDKLL HGVGEHPGRL IFTIVKIETD EGVIGYGETG GGGYSLSPMI
EKLKTSLIGE DLNIRRLRWK VASPISATYY NQLLPQIWFP IETALLDIKG KALGISISDQ
IGGKVKDEIE VSAYIFPTPN TLTVQELVNK VEKIVKEGGF RVVKLKTGVF SPKHEIDVVK
ELAERLPYIK FRLDPNGAWS LSEALYVARS LEGVNIEYFE DPVWTTNGLK AFRELSKYPV
ATNTVAIKFE DLPNVFLRDA VDIVLGDPHW WYGIYGFLEL SASLWSLGLE LGMHSPTETG
IALAAMLHAA SASPNLAYAI DTHYVHLSDD IIKRPFKISE GKIKVPTEPG LGVDVDENKI
DKYQQLYEEE GEYTYHQVEL TKEIVMIPRR SFINCKCHPY
//
