ID C3NK27_SULIN Unreviewed; 403 AA.
AC C3NK27;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=site-specific DNA-methyltransferase (cytosine-N(4)-specific) {ECO:0000256|ARBA:ARBA00012185};
DE EC=2.1.1.113 {ECO:0000256|ARBA:ARBA00012185};
GN OrderedLocusNames=YN1551_2288 {ECO:0000313|EMBL:ACP49270.1};
OS Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2).
OC Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Sulfolobus.
OX NCBI_TaxID=419942 {ECO:0000313|EMBL:ACP49270.1, ECO:0000313|Proteomes:UP000006818};
RN [1] {ECO:0000313|EMBL:ACP49270.1, ECO:0000313|Proteomes:UP000006818}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Y.N.15.51 / Yellowstone #2 {ECO:0000313|Proteomes:UP000006818};
RX PubMed=19435847; DOI=10.1073/pnas.0808945106;
RA Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J.;
RT "Biogeography of the Sulfolobus islandicus pan-genome.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-
CC methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:16857, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:13674,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:85452, ChEBI:CHEBI:137933; EC=2.1.1.113;
CC Evidence={ECO:0000256|ARBA:ARBA00001893};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family. N(4)
CC subfamily. {ECO:0000256|ARBA:ARBA00010203}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP001404; ACP49270.1; -; Genomic_DNA.
DR RefSeq; WP_012717837.1; NC_012623.1.
DR AlphaFoldDB; C3NK27; -.
DR REBASE; 20778; M.SisYNORF2288P.
DR GeneID; 7809263; -.
DR KEGG; sin:YN1551_2288; -.
DR HOGENOM; CLU_027633_1_0_2; -.
DR Proteomes; UP000006818; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0015667; F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002941; DNA_methylase_N4/N6.
DR InterPro; IPR017985; MeTrfase_CN4_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR Pfam; PF01555; N6_N4_Mtase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
DR PROSITE; PS00093; N4_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 34..87
FT /note="DNA methylase N-4/N-6"
FT /evidence="ECO:0000259|Pfam:PF01555"
SQ SEQUENCE 403 AA; 47764 MW; 10DDDEF1FEF3ADD2 CRC64;
MQTSIDDFLN NKYRSVLFRD IVKLRTNYAT HDLYPYPAKF IPNVIRYFIE AYTKPGETLF
DPFAGSGTVA IEAEITGRNY ILWDLNPIIE ILVKAETWKD EISEKIFEID FNYNKSFIPK
WKNLGYWHPK EFIAQLSKLW AYYHDHPNPL VAIPLFKITK YFSYAELEFP KLYKSKFAIE
RVNELLNSNW KEIMRDMYWK EVERVIRKVK EFQSLCKCVS SGKVYGGVDV LSESPPNVNA
VITSPPYLQA QEYIRTFKIE LYWLGYDDNK IKELSKKEIP YNKPPNVEIR SKTFKEYLEK
IEEFGNKKLV DIYITYFRSL TYFFGKVNAR TLGIFVGPVK VRTLRVPIDE ILKEHLESLG
WKHEVTFIDK IVSRRIKEVY KNPATKLEDE RTPTEHLLIM KKN
//
