ID C3QHF7_9BACE Unreviewed; 1441 AA.
AC C3QHF7;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Heavy metal efflux pump, CzcA family {ECO:0000313|EMBL:EEO51391.1};
GN Name=czcA {ECO:0000313|EMBL:EEO51391.1};
GN ORFNames=BSAG_03102 {ECO:0000313|EMBL:EEO51391.1};
OS Bacteroides sp. D1.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=556258 {ECO:0000313|EMBL:EEO51391.1, ECO:0000313|Proteomes:UP000003361};
RN [1] {ECO:0000313|EMBL:EEO51391.1, ECO:0000313|Proteomes:UP000003361}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=D1 {ECO:0000313|EMBL:EEO51391.1,
RC ECO:0000313|Proteomes:UP000003361};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Strauss J., Sibley C.,
RA White A., Allen-Vercoe E., Young S.K., Zeng Q., Gargeya S., Fitzgerald M.,
RA Haas B., Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Brown A.,
RA Chapman S.B., Chen Z., Dunbar C., Freedman E., Gearin G., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Howarth C., Larson L., Lui A.,
RA MacDonald P.J.P., Mehta T., Montmayeur A., Murphy C., Neiman D.,
RA Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P.,
RA Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Bacteroides sp. D1.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the outer membrane factor (OMF) (TC 1.B.17)
CC family. {ECO:0000256|ARBA:ARBA00007613}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEO51391.1}.
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DR EMBL; ACAB02000081; EEO51391.1; -; Genomic_DNA.
DR RefSeq; WP_008016017.1; NZ_JH114343.1.
DR HOGENOM; CLU_002755_1_2_10; -.
DR Proteomes; UP000003361; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR Gene3D; 1.20.1600.10; Outer membrane efflux proteins (OEP); 1.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004763; CusA-like.
DR InterPro; IPR003423; OMP_efflux.
DR NCBIfam; TIGR00914; 2A0601; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF24; CATION EFFLUX SYSTEM (ACRB_ACRD_ACRF FAMILY); 1.
DR Pfam; PF00873; ACR_tran; 1.
DR Pfam; PF02321; OEP; 2.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR SUPFAM; SSF56954; Outer membrane efflux proteins (OEP); 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 341..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..420
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 441..464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 476..496
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 541..560
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 875..894
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 901..920
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 926..948
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 979..1001
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1007..1030
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1050..1066
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1441 AA; 160821 MW; 54D5A3097CEEFB81 CRC64;
MFTAIVRFSI KKKLFVGLTT LFLFIGGIYA MLTLPIDAVP DITNNQVQIV TVSPTLAPQE
VEQLITMPIE IAMSNIMNVE DIRSVSRFGL SVVTVVFKES VPTLDARQLI NEQIQSVTSE
IPSELGTPEM MPITTGLGEI YQYILKVAPG YEKKYDAMEL RTIQDWMVKR QLSGIPGIVE
INSFGGYLKQ YEVAVDPDAL FSLNITIGEV FEALSSNNQN TGGSYIEKIK NAYYIRSEGM
ITRIKDIEQI VVTNRNGIPV HISDVGVVRF GSPKRFGAMT KDGEGECVGG IAMMLKGANA
NVVTQELEKR VEKIQQLLPE GVSIEPYLNR SELVNRNIST VVNNLIEGAV IVFLVLILFL
GNLRAGLIVA SVIPLAMLFA FIMMRVFNVT ANLMSLGAID FGIVVDGSIV ILEGILAHIY
GKQFRGRTLT RKEMDKEVEK GASGVARSAT FAVLIILIVF FPILTLNGIE GKYFTPMAKT
LVFCIIGALI LSLTYVPMMA SLFLKHTIVV KPTLADRFFE KLNKTYQHTL RACLRHKWRT
VIVAFSALIG SLFLFTRLGA EFIPTLDEGD FAMQMTLPAG SSLTESIEVS RLAEKALMDK
FPEIKHVVAK IGTAEVPTDP MAVEDADVMI IMKPFKEWTS AGSRAEMVDK MKDALAPLSE
PAEFNFSQPI QLRFNELMTG AKADIAIKLY GEDTHELYER AKEAATFVEK VPGAADVIVE
QTMGLPQLVV KYNRGKIARY GINIQELNTI IRTAYAGEST GVIFENERRF DLVVRLDQEK
VADLNLDKLF VRTSEGIQIP VGEVASIDLV SGPLQINRDA TKRRIVIGVN VRDADIQQVV
SNIQETLNKN IKLKPGYYFE YGGQFENLQN AINTLLVVIP VALMLILLIL FFAFKNITYT
LMVFSTVPLS LIGGIAALWL RGLPFSISAG VGFIALFGVA VLNGILMVNH FNELRKQNTY
SMTTNQIIKR GTPHLLRPVF LTGLVASLGF VPMAIATSAG AEVQRPLATV VIGGLIISTV
LTLLIIPVFY KIVNSFATWR RPGIKLRRPF GGLCLLFLFL PAFVSAQQTQ TVSLEQAIEI
AKQNHPRLKI ANNAIQQAKA TRGEVIEATP TSFSYSWGQL NGENKKDKEL TFEQSLGSLL
TPFYKNALVN RQVKTNTYYR QMVEKEITAE VKRAWAYYQY ATNLCSMYRD QDKMAEELQR
IGELRYQQGE ITLLEKNMMT TIAADLHNRW FQAKEEEKMA LARFQWSCYS NDPIVPVDST
LSLFYTGISD GNLSGAHTAY FQSQADEAKA MLRVEQSHFF PEISVGYTRQ DILPLKNLNA
WMIGVSFPIY FLPQKSKVKQ ARLTATSAQI QADANIRELR NKTLELEASL RRYNESLRYY
TSSALKEADE LTKAANLQLQ QSETGIAEYI QSITTAREIR RGYIETVYQY NIAALEYELF
K
//
