ID C3QRL8_9BACE Unreviewed; 597 AA.
AC C3QRL8;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE RecName: Full=Beta-glucuronidase {ECO:0000256|ARBA:ARBA00016205};
DE EC=3.2.1.31 {ECO:0000256|ARBA:ARBA00012761};
GN ORFNames=BSCG_01375 {ECO:0000313|EMBL:EEO54450.1};
OS Bacteroides sp. 2_2_4.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=469590 {ECO:0000313|EMBL:EEO54450.1};
RN [1] {ECO:0000313|EMBL:EEO54450.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2_2_4 {ECO:0000313|EMBL:EEO54450.1};
RG The Broad Institute Genome Sequencing Platform;
RA Ward D., Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L.,
RA Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C.,
RA Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T.,
RA White J., Yandava C., Allen-Vercoe E., Strauss J., Ambrose C., Lander E.,
RA Nusbaum C., Ilzarbe M., Galagan J., Birren B.;
RT "The Genome Sequence of Bacteroides sp. strain 2_2_4.";
RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401}.
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DR EMBL; EQ973357; EEO54450.1; -; Genomic_DNA.
DR RefSeq; WP_008646531.1; NZ_EQ973357.1.
DR AlphaFoldDB; C3QRL8; -.
DR HOGENOM; CLU_006501_6_3_10; -.
DR Proteomes; UP000003969; Unassembled WGS sequence.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR006101; Glyco_hydro_2.
DR InterPro; IPR006103; Glyco_hydro_2_cat.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR006104; Glyco_hydro_2_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR10066; BETA-GLUCURONIDASE; 1.
DR PANTHER; PTHR10066:SF67; BETA-GLUCURONIDASE; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF02836; Glyco_hydro_2_C; 1.
DR Pfam; PF02837; Glyco_hydro_2_N; 1.
DR PRINTS; PR00132; GLHYDRLASE2.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EEO54450.1};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..597
FT /note="Beta-glucuronidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002931377"
FT DOMAIN 35..197
FT /note="Glycosyl hydrolases family 2 sugar binding"
FT /evidence="ECO:0000259|Pfam:PF02837"
FT DOMAIN 199..290
FT /note="Glycoside hydrolase family 2 immunoglobulin-like
FT beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF00703"
FT DOMAIN 292..551
FT /note="Glycoside hydrolase family 2 catalytic"
FT /evidence="ECO:0000259|Pfam:PF02836"
SQ SEQUENCE 597 AA; 69250 MW; 57E8B996EBF3E5F0 CRC64;
MQIRKKTIVC MLLFILFVGN AVAQNLITNV YGRDIRSLNG KWNAIIDLYD QGRGMKVYRN
QSPKGNTDFY EYSFQGGLRL NVPGDWNSQT PELKYYEGTV WYARHFDAKR LTHKRQFLYF
GAVSYRCRVY LNGAEIGSHE GGFTPFQIEV TDLLNEGENF IAIEVNNRRT KDAIPAMSFD
WWNYGGITRD VLLVTTPQTY LEDYFIQLDK ESPNRMIAKV ALSDKKAGEK ITVSIPELKT
SIDMLTDAEG KAETVFNIKK LERWSSENPK LYEVIVSSAN DRVEEQIGFR NITVKGTDIY
LNGKPTFMCS ISFHEEIPQR MGRAFSEADA AMLLNEAKAL GVNMIRLAHY PQNEYTVRLA
EKMGFILWQE IPVWQGIDFT NNNTRKKAQR MLSEMIKRDQ NRCAVGYWGI ANETQPSKAR
NEFLTSLLET GKQLDTTRLY VAAFDLVRFN REKKRFVMED SFTSQLDVVA VNKYMGWYHP
WPIEPENAVW EVIPDKPLII SEFGGEALYG QSGDENVASS WSEEYQARLY RDNIRMFDNI
PNLRGVSPWI LFDFRSPFRF HPTNQDGWNR KGLVSDQGIR KKAWYLMREY YKTKFGE
//
