ID C3TBU2_ECOLX Unreviewed; 495 AA.
AC C3TBU2;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=Aldehyde dehydrogenase {ECO:0000313|EMBL:ACI84176.1, ECO:0000313|EMBL:QCL48478.1};
GN ORFNames=C9E67_15655 {ECO:0000313|EMBL:QCL48478.1}, ECs1877
GN {ECO:0000313|EMBL:ACI84176.1};
OS Escherichia coli.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=562 {ECO:0000313|EMBL:ACI84176.1};
RN [1] {ECO:0000313|EMBL:ACI84176.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=493/89 {ECO:0000313|EMBL:ACI84176.1}, 86-24
RC {ECO:0000313|EMBL:ACI84177.1}, 87-14 {ECO:0000313|EMBL:ACI84178.1},
RC TB182A {ECO:0000313|EMBL:ACI84179.1}, and TW14359
RC {ECO:0000313|EMBL:ACI84180.1};
RX PubMed=19439656; DOI=10.1073/pnas.0812949106;
RA Leopold S.R., Magrini V., Holt N.J., Shaikh N., Mardis E.R., Cagno J.,
RA Ogura Y., Iguchi A., Hayashi T., Mellmann A., Karch H., Besser T.E.,
RA Sawyer S.A., Whittam T.S., Tarr P.I.;
RT "A precise reconstruction of the emergence and constrained radiations of
RT Escherichia coli O157 portrayed by backbone concatenomic analysis.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:8713-8718(2009).
RN [2] {ECO:0000313|EMBL:QCL48478.1, ECO:0000313|Proteomes:UP000298553}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=143 {ECO:0000313|EMBL:QCL48478.1,
RC ECO:0000313|Proteomes:UP000298553};
RA Bono J.L., Arthur T.M.;
RT "WGA of Escherichia coli O157:H7: comparison of multiple isolates.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|RuleBase:RU003345}.
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DR EMBL; EU901630; ACI84176.1; -; Genomic_DNA.
DR EMBL; EU901631; ACI84177.1; -; Genomic_DNA.
DR EMBL; EU901632; ACI84178.1; -; Genomic_DNA.
DR EMBL; EU901633; ACI84179.1; -; Genomic_DNA.
DR EMBL; EU901634; ACI84180.1; -; Genomic_DNA.
DR EMBL; CP028607; QCL48478.1; -; Genomic_DNA.
DR RefSeq; WP_001009127.1; NZ_WJRH01000012.1.
DR PATRIC; fig|562.7073.peg.2466; -.
DR OMA; KCAKAMR; -.
DR Proteomes; UP000298553; Chromosome.
DR GO; GO:0004030; F:aldehyde dehydrogenase [NAD(P)+] activity; IEA:UniProtKB-EC.
DR CDD; cd07112; ALDH_GABALDH-PuuC; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR PANTHER; PTHR11699:SF291; NADP_NAD-DEPENDENT ALDEHYDE DEHYDROGENASE PUUC; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003345}.
FT DOMAIN 31..489
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 267
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 495 AA; 53283 MW; 5D6A561146C8DA8A CRC64;
MNFHHLAYWQ DKALSLAIEN RLFINGEYTA AAENETFETV DPVTQAPLAN IARGKSVDID
RAVSAARGVF ERGDWSLSSP AKRKAVLNKL ADLIEANAEE LALLETLDTG KPIRHSLRDD
IPGAARAIRW YAEAIDKVYG EVATTSSHEL AMIVREPVGV IAAIVPWNFP LLLTCWKLGP
ALAAGNSVVL KPSEKSPLSA IRLAGLAKEA GLPDGVLNVV TGFGHEAGQA LSRHNDIDAI
AFTGSTRTGK QLLKDAGDSN MKRVWLEAGG KSANIVFADC PDLQQAASAT AAGIFYNQGQ
VCIAGTRLLL EESIADEFLA LLKQQAQNWQ PGHPLDPATT MGTLIDCAHA DSVHSFIQEG
ESKGQLLLDG RNAGLAVAIG PTIIVDVDPN ASLSREEIFG PVLVVTRFTS EEQALQLAND
SQYGLGAAVW TRDLSRAHRM SRRLKAGSVF VNNYNDGDMT VPFGGYKQSG NGRDKSLHAL
EKFTELKTIW ISLEA
//
