ID C3TRI2_ECOLX Unreviewed; 301 AA.
AC C3TRI2;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 112.
DE SubName: Full=Transcriptional activator NhaR {ECO:0000313|EMBL:EFB2195300.1};
DE SubName: Full=Transcriptional activator of nhaA {ECO:0000313|EMBL:ACI71884.1};
DE SubName: Full=Transcriptional activator protein NhaR {ECO:0000313|EMBL:MQK27659.1};
DE SubName: Full=Transcriptional regulator {ECO:0000313|EMBL:ATZ31900.1};
GN Name=nhaR {ECO:0000313|EMBL:ATZ31900.1};
GN ORFNames=CV83915_01553 {ECO:0000313|EMBL:ATZ31900.1}, DNQ45_08630
GN {ECO:0000313|EMBL:PZT66753.1}, ECs0018 {ECO:0000313|EMBL:ACI71884.1},
GN EIZ93_26220 {ECO:0000313|EMBL:MQK27659.1}, FIJ20_24595
GN {ECO:0000313|EMBL:EFB2195300.1}, FPS11_28930
GN {ECO:0000313|EMBL:EFB3618833.1}, HLZ50_14350
GN {ECO:0000313|EMBL:HAJ5151199.1};
OS Escherichia coli.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=562 {ECO:0000313|EMBL:ACI71884.1};
RN [1] {ECO:0000313|EMBL:ACI71884.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=493/89 {ECO:0000313|EMBL:ACI71884.1}, and TB182A
RC {ECO:0000313|EMBL:ACI71887.1};
RX PubMed=19439656; DOI=10.1073/pnas.0812949106;
RA Leopold S.R., Magrini V., Holt N.J., Shaikh N., Mardis E.R., Cagno J.,
RA Ogura Y., Iguchi A., Hayashi T., Mellmann A., Karch H., Besser T.E.,
RA Sawyer S.A., Whittam T.S., Tarr P.I.;
RT "A precise reconstruction of the emergence and constrained radiations of
RT Escherichia coli O157 portrayed by backbone concatenomic analysis.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:8713-8718(2009).
RN [2] {ECO:0000313|EMBL:ATZ31900.1, ECO:0000313|Proteomes:UP000236551}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CV839-15 {ECO:0000313|EMBL:ATZ31900.1,
RC ECO:0000313|Proteomes:UP000236551};
RA Li Z., Song N., Li W., Philip H.R., Bu Z., Siguo L.;
RT "Escherichia coli CV839-15 Genome sequencing and assembly.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:HAJ5151199.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ecoli[ST-219], and Ecoli[ST-219]
RC {ECO:0000313|EMBL:HAJ5151199.1};
RX PubMed=30286803;
RA Souvorov A., Agarwala R., Lipman D.J.;
RT "SKESA: strategic k-mer extension for scrupulous assemblies.";
RL Genome Biol. 19:153-153(2018).
RN [4] {ECO:0000313|EMBL:PZT66753.1, ECO:0000313|Proteomes:UP000249482}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EcMLT {ECO:0000313|EMBL:PZT66753.1,
RC ECO:0000313|Proteomes:UP000249482};
RA Munoz M.E., Moura Q., Ventura P.R.M., Bustos L.R., Ovando B.G.,
RA Terrazas D.I.V., Yarhui N.B., Cerdeira L., Lincopan N.;
RT "Draft genome sequence of mcr-1-harboring Escherichia coli isolated from
RT wound infection of a hospitalized patient, in Bolivia.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:MQK27659.1, ECO:0000313|Proteomes:UP000359125}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A016f {ECO:0000313|EMBL:MQK27659.1,
RC ECO:0000313|Proteomes:UP000359125};
RX PubMed=31642700; DOI=.1289/EHP5251;
RA Li J., Bi Z., Ma S., Chen B., Cai C., He J., Schwarz S., Sun C., Zhou Y.,
RA Yin J., Hulth A., Wang Y., Shen Z., Wang S., Wu C., Nilsson L.E.,
RA Walsh T.R., Borjesson S., Shen J., Sun Q., Wang Y.;
RT "Inter-host Transmission of Carbapenemase-Producing Escherichia coli among
RT Humans and Backyard Animals.";
RL Environ. Health Perspect. 127:107009-107009(2019).
RN [6] {ECO:0000313|EMBL:EFB2195300.1, ECO:0000313|Proteomes:UP000519859}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FSIS11921886 {ECO:0000313|EMBL:EFB2195300.1,
RC ECO:0000313|Proteomes:UP000519859};
RG NARMS: The National Antimicrobial Resistance Monitoring System;
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:EFB3618833.1, ECO:0000313|Proteomes:UP000543252}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PSU-1859 {ECO:0000313|EMBL:EFB3618833.1,
RC ECO:0000313|Proteomes:UP000543252};
RG GenomeTrakr network: Whole genome sequencing for foodborne pathogen traceback;
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:HAJ5151199.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Ecoli[ST-219] {ECO:0000313|EMBL:HAJ5151199.1};
RG NCBI Pathogen Detection Project;
RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC {ECO:0000256|ARBA:ARBA00009437}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; EU906770; ACI71884.1; -; Genomic_DNA.
DR EMBL; EU906773; ACI71887.1; -; Genomic_DNA.
DR EMBL; CP024978; ATZ31900.1; -; Genomic_DNA.
DR EMBL; AASDFP010000103; EFB2195300.1; -; Genomic_DNA.
DR EMBL; AASFMQ010000102; EFB3618833.1; -; Genomic_DNA.
DR EMBL; DABGKZ010000019; HAJ5151199.1; -; Genomic_DNA.
DR EMBL; RYCF01000259; MQK27659.1; -; Genomic_DNA.
DR EMBL; QKWZ01000196; PZT66753.1; -; Genomic_DNA.
DR RefSeq; WP_000062890.1; NZ_LVMX01000135.1.
DR PATRIC; fig|562.6997.peg.3578; -.
DR OMA; MEWLNYH; -.
DR Proteomes; UP000236551; Chromosome.
DR Proteomes; UP000249482; Unassembled WGS sequence.
DR Proteomes; UP000359125; Unassembled WGS sequence.
DR Proteomes; UP000519859; Unassembled WGS sequence.
DR Proteomes; UP000543252; Unassembled WGS sequence.
DR Proteomes; UP000840371; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR CDD; cd08429; PBP2_NhaR; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR005119; LysR_subst-bd.
DR InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR30293:SF2; TRANSCRIPTIONAL ACTIVATOR PROTEIN NHAR; 1.
DR PANTHER; PTHR30293; TRANSCRIPTIONAL REGULATORY PROTEIN NAC-RELATED; 1.
DR Pfam; PF00126; HTH_1; 1.
DR Pfam; PF03466; LysR_substrate; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50931; HTH_LYSR; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 6..63
FT /note="HTH lysR-type"
FT /evidence="ECO:0000259|PROSITE:PS50931"
SQ SEQUENCE 301 AA; 34284 MW; E81FAFC4FC4FD2F1 CRC64;
MSMSHINYNH LYYFWHVYKE GSVVGAAEAL YLTPQTITGQ IRALEERLQG KLFKRKGRGL
EPSELGELVY RYADKMFTLS QEMLDIVNYR KESNLLFDVG VADALSKRLV SSVLNAAVVE
GEPIHLRCFE STHEMLLEQL SQHKLDMIIS DCPIDSTQQE GLFSVRIGEC GVSFWCTNPP
PEKPFPACLE ERRLLIPGRR SMLGRKLLNW FNSQGLNVEI LGEFDDAALM KAFGAMHNAI
FVAPTLYAYD FYADKTVVEI GRVENVMEEY HAIFAERMIQ HPAVQRICNT DYSALFSPAV
R
//
