ID C3TS26_TRICA Unreviewed; 121 AA.
AC C3TS26;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 03-MAY-2023, entry version 45.
DE SubName: Full=Truncated nicotinic acetylcholine receptor subunit a3 {ECO:0000313|EMBL:ACM09851.1};
GN Name=nAChRA3 {ECO:0000313|EMBL:ACM09851.1};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:ACM09851.1};
RN [1] {ECO:0000313|EMBL:ACM09851.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19320762; DOI=10.1111/j.1365-2583.2009.00873.x;
RA Rinkevich F.D., Scott J.G.;
RT "Transcriptional diversity and allelic variation in nicotinic acetylcholine
RT receptor subunits of the red flour beetle, Tribolium castaneum.";
RL Insect Mol. Biol. 18:233-242(2009).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034104}; Multi-pass
CC membrane protein {ECO:0000256|ARBA:ARBA00034104}. Synaptic cell
CC membrane {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034099}.
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DR EMBL; EU930056; ACM09851.1; -; mRNA.
DR AlphaFoldDB; C3TS26; -.
DR HOGENOM; CLU_018074_1_3_1; -.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022848; F:acetylcholine-gated monoatomic cation-selective channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR PANTHER; PTHR18945:SF895; NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA3, ISOFORM B; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR PRINTS; PR00254; NICOTINICR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023257};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:ACM09851.1};
KW Signal {ECO:0000256|SAM:SignalP}; Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..121
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002932846"
FT DOMAIN 25..115
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
SQ SEQUENCE 121 AA; 14157 MW; DB26EB94C78A612C CRC64;
MKSLVGIMWI VLVLISGCSG NPDAKRLYDD LLSNYNKLVR PVVNVSDALT VKIKLKLSQL
IDVNLKNQIM TTNLWVEQSW YDYKLKWDPK EYGGVEMLHV PSDHIWRPDI VLYNNCFQCR
W
//
