ID C3U1A7_TRYRA Unreviewed; 760 AA.
AC C3U1A7;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Group II trans-sialidase superfamily {ECO:0000313|EMBL:ACO87651.1};
OS Trypanosoma rangeli.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Herpetosoma.
OX NCBI_TaxID=5698 {ECO:0000313|EMBL:ACO87651.1};
RN [1] {ECO:0000313|EMBL:ACO87651.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=M/CAN/VE/82/DOG82 {ECO:0000313|EMBL:ACO87651.1};
RX PubMed=19433050; DOI=10.1016/j.actatropica.2009.05.003;
RA Pena C.P., Lander N., Rodriguez E., Crisante G., Anez N., Ramirez J.L.,
RA Chiurillo M.A.;
RT "Molecular analysis of surface glycoprotein multigene family TrGP expressed
RT on the plasma membrane of Trypanosoma rangeli epimastigotes forms.";
RL Acta Trop. 111:255-262(2009).
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DR EMBL; FJ404803; ACO87651.1; -; Genomic_DNA.
DR AlphaFoldDB; C3U1A7; -.
DR CAZy; GH33; Glycoside Hydrolase Family 33.
DR VEuPathDB; TriTrypDB:TRSC58_06671; -.
DR VEuPathDB; TriTrypDB:TRSC58_06964; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13859; BNR_3; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..760
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002933026"
FT TRANSMEM 742..759
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 66..403
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 661..731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 661..693
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 696..711
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 712..731
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 760 AA; 83017 MW; CF11D34E53AB1551 CRC64;
MSRHMFSFSV LLFFVLLMAF GSTAVYAERN TRNKMKLPEA VDLFVARQTT VVTHGLIELR
DSFAFPSLAS AGGVLVALAE GNTNFQEAQQ EKRWVTYADV VAGYIDSAKS WPSFVAEVRA
NDWKAHSIFN TSVQEEHNGS LRYVYKPTTI SKGNKVFLLV GGPHHKYDSS SKKWTKSSRH
FDLLVGETTQ DKVIQWGKPT SLWPQIKPSA KQRGLKQLLG GGGSGVVMED GTLVFPVTAR
EGGVNNFVCM IIYSKDDGKN WVLAQGVAHS GCTDPLIVEW ERGQLLMVAK CNSLSKVFES
RDMGATWTGT VRILTRLSLI FLPNTFLTAD TMESLTTASI AGKKVMLYTQ KGVPPGDTLQ
TTALYLWVTD NNRTFHVGPI SMDTTRNRMT ANTLLHSNDA LHLLQERASK TTTGVSLASL
TDALKTITSI LETWAKLDAS LSNSSVPTAG LVGVLSDASG DGTWSDAYRC VDATVTNATK
VEDGFKFTGS VSYAMWPVNM RKYHNVHGFV NYAFTLVATV TIDEVPNGSA PLLDTSLEDN
EKTTFVGLSY TTEKRWETVF NGTPTRSEIT WEVGKAYQVA LVLRYNEGFV YVDGVLVGSS
DTLPTSEAQG HDISYFHFGG GIDGSATVKN VFLYNRRLSV MQLKKVDNSI AFWKSAGDSS
KVSEKRAGDS SKASEHRPGD SSKAFEHRPG DSSSAFEQRA GDSSDASEQR AGDSSKVSEK
RAVDSSKVSE HRAGDSSMRA DVFLVLICFL GLWGVAALVL
//
