ID C3U3H0_9SAUR Unreviewed; 229 AA.
AC C3U3H0;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086};
DE Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE Flags: Fragment;
GN Name=BDNF {ECO:0000313|EMBL:ACQ57072.1};
OS Amphisbaena camura.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Laterata;
OC Lacertibaenia; Amphisbaenia; Amphisbaenidae; Amphisbaena.
OX NCBI_TaxID=261507 {ECO:0000313|EMBL:ACQ57072.1};
RN [1] {ECO:0000313|EMBL:ACQ57072.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19405188; DOI=10.1016/j.ympev.2009.01.014;
RA Mott T., Vieites D.R.;
RT "Molecular phylogenetics reveals extreme morphological homoplasy in
RT Brazilian worm lizards challenging current taxonomy.";
RL Mol. Phylogenet. Evol. 51:190-200(2009).
CC -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC located either in the central nervous system or directly connected to
CC it. {ECO:0000256|ARBA:ARBA00002323, ECO:0000256|RuleBase:RU364086}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR EMBL; FJ441855; ACQ57072.1; -; Genomic_DNA.
DR AlphaFoldDB; C3U3H0; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01912; BDNFACTOR.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001789-1};
KW Growth factor {ECO:0000256|RuleBase:RU364086}.
FT DOMAIN 115..222
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT DISULFID 123..190
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 168..219
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 178..221
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACQ57072.1"
FT NON_TER 229
FT /evidence="ECO:0000313|EMBL:ACQ57072.1"
SQ SEQUENCE 229 AA; 25679 MW; 33A35CB6E5BD1EDF CRC64;
AAPMKEVSIR GPGSLAYPSL RTQGNLENLG GPNDASGGLT SLADTFEHVI EELLDEQQVI
QPSKQNKDAD LYSSRVMLSS QVPLEPPLLF LLEEYKNYLD AANMSMRVRR HSDPARRGEL
SVCDSTSEWV TAAEKKTAVD MSGATVTVLE KVPVPKGQLK QYFYETKCNS KGYTKEGCRG
IDKRYWNSQC RTTQSYVRAL TMDNKKRVGW RFIRIDTSCV CTLTIKRGR
//
