ID C3U816_9HIV1 Unreviewed; 240 AA.
AC C3U816;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Pol protein {ECO:0000313|EMBL:ACP00071.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:ACP00071.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ACP00071.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ACP00071.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=M74clone5 {ECO:0000313|EMBL:ACP00071.1};
RA Foley B.T.;
RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACP00071.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=M74clone5 {ECO:0000313|EMBL:ACP00071.1};
RX PubMed=19119321; DOI=10.1371/journal.pone.0004096;
RA Moorthy A., Gupta A., Bhosale R., Tripathy S., Sastry J., Kulkarni S.,
RA Thakar M., Bharadwaj R., Kagal A., Bhore A.V., Patil S., Kulkarni V.,
RA Venkataramani V., Balasubramaniam U., Suryavanshi N., Ziemniak C.,
RA Gupte N., Bollinger R., Persaud D.;
RT "Nevirapine resistance and breast-milk HIV transmission: effects of single
RT and extended-dose nevirapine prophylaxis in subtype C HIV-infected
RT infants.";
RL PLoS ONE 4:E4096-E4096(2009).
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DR EMBL; FJ520273; ACP00071.1; -; Genomic_DNA.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral release from host cell {ECO:0000256|ARBA:ARBA00023113};
KW Virion maturation {ECO:0000256|ARBA:ARBA00023113}.
FT DOMAIN 41..231
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACP00071.1"
FT NON_TER 240
FT /evidence="ECO:0000313|EMBL:ACP00071.1"
SQ SEQUENCE 240 AA; 28043 MW; 3C45468B7E5F7143 CRC64;
PVETVPVKLK PGMDGPKIKQ WPLTEEKIKA LTAICEEMEK EGKISKIGPE NPYNTPIFAI
KKKDSTKWRK LVDFRELNKR TQDFWEVQLG IPHPAGLKKK KSVTVLDVGD AYFSVPLYED
FRKYTAFTIP STNNETPGIR YQYNVLPQGW KGSPAIFQHS MTKILEPFRA RNPEIVIYQY
MDDLYVGSDL EIMQHRAKIE ELREHLLKWG FTTPDKKHQK EPPFLWMGYE LHPDKWTVQP
//
