ID C3UHQ6_9HIV1 Unreviewed; 233 AA.
AC C3UHQ6;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Pol protein {ECO:0000313|EMBL:ACP03461.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:ACP03461.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ACP03461.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ACP03461.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=M20clone61 {ECO:0000313|EMBL:ACP03461.1};
RA Foley B.T.;
RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACP03461.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=M20clone61 {ECO:0000313|EMBL:ACP03461.1};
RX PubMed=19119321; DOI=10.1371/journal.pone.0004096;
RA Moorthy A., Gupta A., Bhosale R., Tripathy S., Sastry J., Kulkarni S.,
RA Thakar M., Bharadwaj R., Kagal A., Bhore A.V., Patil S., Kulkarni V.,
RA Venkataramani V., Balasubramaniam U., Suryavanshi N., Ziemniak C.,
RA Gupte N., Bollinger R., Persaud D.;
RT "Nevirapine resistance and breast-milk HIV transmission: effects of single
RT and extended-dose nevirapine prophylaxis in subtype C HIV-infected
RT infants.";
RL PLoS ONE 4:E4096-E4096(2009).
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DR EMBL; FJ523919; ACP03461.1; -; Genomic_DNA.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral release from host cell {ECO:0000256|ARBA:ARBA00023113};
KW Virion maturation {ECO:0000256|ARBA:ARBA00023113}.
FT DOMAIN 41..231
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACP03461.1"
FT NON_TER 233
FT /evidence="ECO:0000313|EMBL:ACP03461.1"
SQ SEQUENCE 233 AA; 27013 MW; E5BC53AE2064CB53 CRC64;
PVETVPVKLK PGMDGPKVKQ WPLTEEKIKA LTAICDEMEK EGKITKIGPE NPYNTPIFAI
KKKDSTKWRK LVDFRELNKR TQDFWEVQLG IPHPAGLKKK KSVTVLDVGD AYFSVPLDKD
FRKYTAFTIP SINNETPGIR YQYNVLPQGW KGSPAIFQSS MTKILEPFRA RNPEIVIYQY
MDDLYVGSDL EIGQHRAKIE ELREHLLKWG FTTPDKKHQK EPPFLWMGYE LHP
//
