ID C3UYX7_9HIV1 Unreviewed; 732 AA.
AC C3UYX7;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|ARBA:ARBA00015406};
DE AltName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:ACO91343.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ACO91343.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ACO91343.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=432_30 {ECO:0000313|EMBL:ACO91343.1};
RX PubMed=19211740; DOI=10.1128/JVI.02486-08;
RA Ince W.L., Harrington P.R., Schnell G.L., Patel-Chhabra M., Burch C.L.,
RA Menezes P., Price R.W., Eron J.J.Jr., Swanstrom R.I.;
RT "Major coexisting human immunodeficiency virus type 1 env gene
RT subpopulations in the peripheral blood are produced by cells with similar
RT turnover rates and show little evidence of genetic compartmentalization.";
RL J. Virol. 83:4068-4080(2009).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004578}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; FJ798558; ACO91343.1; -; Genomic_DNA.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 1.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR036377; Gp120_core_sf.
DR InterPro; IPR000328; GP41-like.
DR InterPro; IPR000777; HIV1_Gp120.
DR Pfam; PF00516; GP120; 1.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF56502; gp120 core; 1.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:ACO91343.1};
KW Virion {ECO:0000313|EMBL:ACO91343.1}.
FT TRANSMEM 387..413
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 554..581
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 20..386
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 406..595
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACO91343.1"
SQ SEQUENCE 732 AA; 83211 MW; 1CCCC1FE9CAC34ED CRC64;
LNCTDLQNGT IQNVTSGSGG AMEKGEIKNC SFNITTTMKN KVQKEYATFY RLDVVKINED
NTSYRLTSCN ASVITQACPK ITFEPIPIHY CAPAGFAILK CNDKKFNGSG PCTNVSTVQC
THGIKPVVST QLLLNGSLAE EEIVIRSENF SNNAKTILVQ LKDAVEINCT RPNNNTRKRI
TMGPGRVYYT TGQIIGNIRQ AHCNISRRKW NDTLRQIVIK LREQFGNKTI VFNQSSGGDP
EIVMHNFNCG GEFFYCNSTQ LFNSTWNNTS NWNDTSTGND TDIILPCKIR QIINLWQEVG
KAMYAPPIKG QIRCSSNITG LILVRDGGDN NSTNESNTKP EIFRPGGGNM RDNWRSELYK
YKVIQIEPLG IAPTKAKRRV VQREKRAVGV LGAMFLGFLG AAGSTMGAAS MALTVQARQL
LSGIVQQQNN LLRAIEAQQH LLQLTVWGVK QLQARVLAVE RYLKDQQLLG IWGCSGKLIC
TTAVPWNTSW SNKTQKQIWE NMTWMQWEKE IDNYTGLIYT LLEESQNQQE KNEQELLELD
KWASLWNWFD ISNWLWYIKI FIMIVGGLIG LRIVFAVFTI VNRVRQGYSP LSFQTRLPVS
RGPDRPEGIE EEGGERDRDR SIRLVDGFLA LIWDDLRSLC LFLYHRLRDL LLIVARIVEL
LGRRGREVLK YWWNLLQYWS QELKNSAVSL LNTTAIVVAE GTDRVIEIVQ RAYRAFIHIP
RRIRQGFERA LL
//
