ID C3VFZ0_ANOME Unreviewed; 147 AA.
AC C3VFZ0;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=GPN-loop GTPase {ECO:0000256|RuleBase:RU365059};
DE EC=3.6.5.- {ECO:0000256|RuleBase:RU365059};
DE Flags: Fragment;
GN ORFNames=AGAP010314 {ECO:0000313|EMBL:ACQ43143.1};
OS Anopheles merus (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30066 {ECO:0000313|EMBL:ACQ43143.1};
RN [1] {ECO:0000313|EMBL:ACQ43143.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MER_V2A {ECO:0000313|EMBL:ACQ43143.1}, and MER_V2B
RC {ECO:0000313|EMBL:ACQ43169.1};
RA White B.J., Cheng C., Simard F., Costantini C., Besansky N.J.;
RT "Genetic association of physically unlinked islands of genomic divergence
RT in incipient species of Anopheles gambiae.";
RL Mol. Ecol. 19:925-939(2010).
CC -!- FUNCTION: Small GTPase required for proper nuclear import of RNA
CC polymerase II (RNAPII). May act at an RNAP assembly step prior to
CC nuclear import. {ECO:0000256|RuleBase:RU365059}.
CC -!- SUBUNIT: Binds to RNA polymerase II. {ECO:0000256|RuleBase:RU365059}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU365059}.
CC Nucleus {ECO:0000256|RuleBase:RU365059}.
CC -!- SIMILARITY: Belongs to the GPN-loop GTPase family.
CC {ECO:0000256|ARBA:ARBA00005290, ECO:0000256|RuleBase:RU365059}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FJ863551; ACQ43143.1; -; Genomic_DNA.
DR EMBL; FJ863577; ACQ43169.1; -; Genomic_DNA.
DR AlphaFoldDB; C3VFZ0; -.
DR VEuPathDB; VectorBase:AMEM012120; -.
DR VEuPathDB; VectorBase:AMEM21_012480; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR004130; Gpn.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR21231:SF8; GPN-LOOP GTPASE 1; 1.
DR PANTHER; PTHR21231; XPA-BINDING PROTEIN 1-RELATED; 1.
DR Pfam; PF03029; ATP_bind_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU365059};
KW GTP-binding {ECO:0000256|RuleBase:RU365059};
KW Hydrolase {ECO:0000256|RuleBase:RU365059};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU365059}.
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACQ43143.1"
FT NON_TER 147
FT /evidence="ECO:0000313|EMBL:ACQ43143.1"
SQ SEQUENCE 147 AA; 16753 MW; 2C1AC575C0D5E8D1 CRC64;
LFSTKFGKVI DLIQNAQETH EYCIIDTPGQ IEVFTWSASG TIITEALATA FPTVIVYVMD
IVRSTSPTTF MSNMLYACSI LYKARLPFVI AMNKIDIQEH NFAMQWMQDF EAFQESLENE
TAYISNLTRT MSLTLDEFYK NLKSCGV
//
