ID C3W948_SHEEP Unreviewed; 700 AA.
AC C3W948;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Cyclic nucleotide gated channel alpha 3 protein {ECO:0000313|EMBL:CAY32647.1};
GN Name=cnga3 {ECO:0000313|EMBL:CAY32647.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|EMBL:CAY32647.1};
RN [1] {ECO:0000313|EMBL:CAY32647.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19874885;
RA Reicher S., Seroussi E., Gootwine E.;
RT "A mutation in gene CNGA3 is associated with day blindness in sheep.";
RL Genomics 95:101-104(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FN377574; CAY32647.1; -; mRNA.
DR AlphaFoldDB; C3W948; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.20.5.300; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR032406; CLZ_dom.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45638:SF6; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL ALPHA-3; 1.
DR PANTHER; PTHR45638; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR Pfam; PF16526; CLZ; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS00889; CNMP_BINDING_2; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 321..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 497..611
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 109..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 645..683
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..172
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 700 AA; 80343 MW; AD4DA7E8FA16782D CRC64;
MAKISTQYSH PTRTHPSVRT SDRDLDCIEN GLSRTHLPCE ETSSALQEGI AMETRGLAES
RQSSFTSQGP TRLSRLIISL RAWTARHLHR EDQRPDSLLE RFRGAELKEV SSRESHTQFN
VGSQEPPDRG RSDWPLARNN TNTCNNSEKD DKAKKEEKEK KEDPKKEEKK KDSVVVDPSS
NMYYHWLTVI AVPVFYNWCL LVCRACFDEL QSEHLMLWLV LDYSADILYG VDVLVRARTG
FLEQGLMVMD TSRLWKHYTK TLHFKLDVLS LVPTDLAYLK LGMNYPELRF NRLLKLPRLF
EFFDRTETRT NYPNMFRIGN LVLYILIIIH WNACIYFAIS KFIGFGTDSW VYPNISNPEY
GRLSRKYIYS LYWSTLTLTT IGETPPPVKD EEYLFVVIDF LVGVLIFATI VGNVGSMISN
MNASRAEFQA KIDSIKQYMQ FRKVTKDLET RVIRWFDYLW ANKKTVDEKE VLKSLPDKLK
AEIAINVHLD TLRKVRIFQD CEAGLLVELV LKLRPAVFSP GDYICKKGDI GREMYIIKEG
KLAVVAEDGI TQFVVLGDGS YFGEISILNI KGSKSGNRRT ANIRSIGYSD LFCLSKDDLM
EALTEYPEAK KALEEKGRQI LMKDNLIDEE LARAGADPKD LEEKVEHLET SLDTLQTRFA
RLLAEYNATQ MKVKQRLSQL ESQVKMGLPP DGDALQTEAS
//
