ID C3XDL6_9HELI Unreviewed; 448 AA.
AC C3XDL6;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE RecName: Full=malate dehydrogenase (quinone) {ECO:0000256|ARBA:ARBA00013026};
DE EC=1.1.5.4 {ECO:0000256|ARBA:ARBA00013026};
DE AltName: Full=MQO {ECO:0000256|ARBA:ARBA00031550};
DE AltName: Full=Malate dehydrogenase [quinone] {ECO:0000256|ARBA:ARBA00030660};
GN ORFNames=HRAG_00162 {ECO:0000313|EMBL:EEO23105.1};
OS Helicobacter bilis ATCC 43879.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=613026 {ECO:0000313|EMBL:EEO23105.1, ECO:0000313|Proteomes:UP000005085};
RN [1] {ECO:0000313|EMBL:EEO23105.1, ECO:0000313|Proteomes:UP000005085}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43879 {ECO:0000313|EMBL:EEO23105.1,
RC ECO:0000313|Proteomes:UP000005085};
RX PubMed=25212613;
RA Shen Z., Sheh A., Young S.K., Abouelliel A., Ward D.V., Earl A.M.,
RA Fox J.G.;
RT "Draft genome sequences of six enterohepatic helicobacter species isolated
RT from humans and one from rhesus macaques.";
RL Genome Announc. 2:e00857-e00814(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001139};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC oxaloacetate from (S)-malate (quinone route): step 1/1.
CC {ECO:0000256|ARBA:ARBA00005012}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEO23105.1}.
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DR EMBL; ACDN02000003; EEO23105.1; -; Genomic_DNA.
DR RefSeq; WP_005216724.1; NZ_KI392032.1.
DR AlphaFoldDB; C3XDL6; -.
DR eggNOG; COG0579; Bacteria.
DR HOGENOM; CLU_613842_0_0_7; -.
DR OrthoDB; 5337444at2; -.
DR UniPathway; UPA00223; UER01008.
DR Proteomes; UP000005085; Unassembled WGS sequence.
DR GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006231; MQO.
DR PANTHER; PTHR43104; L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43104:SF2; L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF06039; Mqo; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000005085}.
SQ SEQUENCE 448 AA; 50266 MW; 96551B9323D205E9 CRC64;
MNEFDVVIIG GGVSGCCTFY TLTEYSDIKK IAIIEKETKL AQISSSHKAN SQTIHDGSIE
TNYSAEKARK VKLSAQKVRN FCLKENLQNK VIYNMQKMAI GVGDHECEVM TKRHEDFQHI
FPGLKFYTKE DIKVMEPKVI EGKNGGDRPE NVVGSGFDSD WCAVNYEALS EYFIQKAKEK
NPQNEVFLGF RVNRIEAKNT GYAVVGADGR EIYAKFVLVD AGSYSLPLAQ RAGYGLDLGC
LPVGGEFYFA PNLLKGKVYG VQNPKLPFAA LHGDPDVFVE GKTRLGPTAL ATLRLENSKH
FFDVLSPDLL KLDLHLDVIK VTYDLLSDSE IRNYILRNIF FHLPFFGKRL FIKDAQKIIP
SLKLEDITFA KGYGEVRPQV VDRTAKKLEL GEKKIRTGKG MTFNMTPSPG ATSCLQNAMI
DSEEIVAFLH ANFDKERFLK ELSPEELQ
//
