ID   C3XQQ6_BRAFL            Unreviewed;       655 AA.
AC   C3XQQ6;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   RecName: Full=VWFA domain-containing protein {ECO:0000259|PROSITE:PS50234};
GN   ORFNames=BRAFLDRAFT_93664 {ECO:0000313|EMBL:EEN69632.1};
OS   Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC   Branchiostomatidae; Branchiostoma.
OX   NCBI_TaxID=7739;
RN   [1] {ECO:0000313|EMBL:EEN69632.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN69632.1};
RC   TISSUE=Testes {ECO:0000313|EMBL:EEN69632.1};
RX   PubMed=18563158; DOI=10.1038/nature06967;
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA   Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA   Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA   Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA   Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA   Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA   Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA   Satoh N., Rokhsar D.S.;
RT   "The amphioxus genome and the evolution of the chordate karyotype.";
RL   Nature 453:1064-1071(2008).
CC   -!- SIMILARITY: Belongs to the calcium channel subunit alpha-2/delta
CC       family. {ECO:0000256|ARBA:ARBA00007060}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GG666455; EEN69632.1; -; Genomic_DNA.
DR   RefSeq; XP_002613623.1; XM_002613577.1.
DR   AlphaFoldDB; C3XQQ6; -.
DR   STRING; 7739.C3XQQ6; -.
DR   eggNOG; KOG2353; Eukaryota.
DR   InParanoid; C3XQQ6; -.
DR   GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR013608; VWA_N.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10166; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED; 1.
DR   PANTHER; PTHR10166:SF69; VWFA DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00092; VWA; 1.
DR   Pfam; PF08399; VWA_N; 2.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022673};
KW   Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW   Calcium transport {ECO:0000256|ARBA:ARBA00022673};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|ARBA:ARBA00022882};
KW   Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           27..655
FT                   /note="VWFA domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002933153"
FT   DOMAIN          301..501
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
SQ   SEQUENCE   655 AA;  73488 MW;  4984B832BF66DA86 CRC64;
     MAPCGRLAGW ALLALTAAVI LSEAAAKRPF PQLRDVRDWA RVLATDLKAM VDTAKFDELS
     TAYANEVQAG RLSLQTINGT QLIETSTNKM ASSIAVRTKA LKSLSEAAEA AVANHNYNQS
     IKVADVPYYS AMDGIPEHRL PGLADDKWLG GQTNRTNSSI HIPVNIYEQD AHVLNVIAWS
     SHLDSVFIDN WQQNQDSTHI QHFNVSMSFF LPPDAHVLNV IAWSSHLDSV FIDNWQQNQE
     TLPWQAFASQ TGVFRMYPAR PMQPHRFGSR TLTIADVPRR FDEFDARMTQ WYQQTISSPK
     DMLILLDTSG SVEGRSLSLM KHTTWFLLDR LTEDDYVATG YFNAYAQAVS CLSSFVQATT
     HNKEVIHKSL DNLEAADQAN YYAGLEYAFK IFNNFEMEDR FENQGAECNK VIVLVTENAE
     LYPEAVFQKY NPDRNIRVFV IVVGEPIHDW SVLQKMACDN RGYFSTVRSD GAAREASGDF
     GQVLSRPVAL ENSKEVTFSK IFMSEKGDDF EVYVSYPVIN TTMDNPPYIA NDGSCKLDDS
     ACANQAVLGV VSVPWPVKEM RKSLPLRELG HGGYAFIINN NGFVVLHPHL TPEDAFYSKP
     PTIDLLDIEF TNPDKEAMRN KMVKLETGRD VINTLHKTHD HGFGPLKATQ LGSWF
//