ID   C3XSV1_BRAFL            Unreviewed;       269 AA.
AC   C3XSV1;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   24-JAN-2024, entry version 60.
DE   RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
DE   Flags: Fragment;
GN   ORFNames=BRAFLDRAFT_213197 {ECO:0000313|EMBL:EEN69022.1};
OS   Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC   Branchiostomatidae; Branchiostoma.
OX   NCBI_TaxID=7739;
RN   [1] {ECO:0000313|EMBL:EEN69022.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN69022.1};
RC   TISSUE=Testes {ECO:0000313|EMBL:EEN69022.1};
RX   PubMed=18563158; DOI=10.1038/nature06967;
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA   Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA   Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA   Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA   Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA   Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA   Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA   Satoh N., Rokhsar D.S.;
RT   "The amphioxus genome and the evolution of the chordate karyotype.";
RL   Nature 453:1064-1071(2008).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GG666459; EEN69022.1; -; Genomic_DNA.
DR   RefSeq; XP_002613013.1; XM_002612967.1.
DR   AlphaFoldDB; C3XSV1; -.
DR   eggNOG; KOG3523; Eukaryota.
DR   InParanoid; C3XSV1; -.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR047271; Ephexin-like.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR12845:SF5; EPHEXIN, ISOFORM D; 1.
DR   PANTHER; PTHR12845; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
FT   DOMAIN          7..198
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   NON_TER         269
FT                   /evidence="ECO:0000313|EMBL:EEN69022.1"
SQ   SEQUENCE   269 AA;  31202 MW;  25954BC17BF45670 CRC64;
     MSTQQRQLQE AIFEVLKTEG SYLHSMTIFV QHFMSDEELR RSIKSSEYKA LMSNSGEVLK
     ASQLFFNDLK ARQEKNVVVN DICDIIVKHA KKGFLVPYKN YCKNLPLQES TLKSLTEGTQ
     SQELNQNFCD ALKKLEMDER CGKLPFSSFL LLPMQRITRF PLMVERIMNM READTKLFNT
     ALDALTAVRN VSKQCNQATR KEQQMIELED LVKKLAFDKV NPNFSLLNKE RSIIKQGELT
     WIPVRGKKTK NHIVLLTDYL LVTKKKEDK
//