ID C3XW80_BRAFL Unreviewed; 441 AA.
AC C3XW80;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 67.
DE RecName: Full=Integrator complex subunit 12 {ECO:0000256|ARBA:ARBA00016814};
GN ORFNames=BRAFLDRAFT_63748 {ECO:0000313|EMBL:EEN67614.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN67614.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN67614.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN67614.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the Integrator subunit 12 family.
CC {ECO:0000256|ARBA:ARBA00006009}.
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DR EMBL; GG666471; EEN67614.1; -; Genomic_DNA.
DR RefSeq; XP_002611604.1; XM_002611558.1.
DR AlphaFoldDB; C3XW80; -.
DR STRING; 7739.C3XW80; -.
DR eggNOG; KOG4323; Eukaryota.
DR InParanoid; C3XW80; -.
DR GO; GO:0032039; C:integrator complex; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0034472; P:snRNA 3'-end processing; IBA:GO_Central.
DR CDD; cd15501; PHD_Int12; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR039054; Int12_PHD.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13415:SF2; INTEGRATOR COMPLEX SUBUNIT 12; 1.
DR PANTHER; PTHR13415; NUCLEAR FACTOR-RELATED; 1.
DR Pfam; PF00628; PHD; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 168..224
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 35..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 232..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 277..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..95
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 350..375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 406..420
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..441
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 441 AA; 46962 MW; 2027EEFC2600B5D6 CRC64;
MATFELDPVF VKALGYLRSK SKDSTDKLKA LVDAALNKSS PSLSTSSVIA GKHDKDVEGR
KGSPHGQMSR LMVPGQKERR SPSLSGSSTG RSTPEPPKKQ PDKRSLEKLK QDLTDLNKEH
KKPKLEKPDP PMVREGSPPA LKKEQSSDEE EGEEGMETSA DEFAEEMGLV CVICRQMNVT
PGNQLVECAE CHNLYHQDCH RPPVTDSDVN DPRKVWYCQR CTRTIRKMNK IQALPPLKAS
KAQKTKPSAT MSSSREKEHS TVKPKTPDLS TMQLFKRSET SSMTSSSTLS STGSGSQLTG
LASWAANISG KSSLPKTPTT TKAPTGPFSS SKPAAATSGK QGLAAMKAAV VSKSSSSGSS
SKYLSSSSSV GSSMAKPGGG SGKPPSSASV KPSGSGAAKS GGNGGRMLQL PTSQSQDANK
RLQMMKKKAA AKMQQKKQSR F
//
