ID C3YNT5_BRAFL Unreviewed; 1732 AA.
AC C3YNT5;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=NACHT domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=BRAFLDRAFT_82622 {ECO:0000313|EMBL:EEN58045.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN58045.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN58045.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN58045.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
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DR EMBL; GG666535; EEN58045.1; -; Genomic_DNA.
DR RefSeq; XP_002602033.1; XM_002601987.1.
DR eggNOG; ENOG502RZIW; Eukaryota.
DR InParanoid; C3YNT5; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd01671; CARD; 2.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR041249; HEPN_DZIP3.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46844; SLR5058 PROTEIN; 1.
DR PANTHER; PTHR46844:SF1; SLR5058 PROTEIN; 1.
DR Pfam; PF00619; CARD; 2.
DR Pfam; PF18738; HEPN_DZIP3; 1.
DR Pfam; PF05729; NACHT; 2.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50209; CARD; 2.
DR PROSITE; PS50837; NACHT; 2.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 228..318
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 381..498
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT DOMAIN 759..849
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 946..1063
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 1732 AA; 198476 MW; C02CE783282C91B8 CRC64;
MALSKPYTPG TARGAKLAAL LVDEGTALVR KILEDEIQKM NPPSLREQLM KHKEYLYRNH
VFKKQGKNHR ANLNPGQKKT LYPPNGMIIC NVVTMMIPVC NIPDTAQGFD ISLLELLLKV
LVWLELGRGA PYSGERDRLR RFRKANYGHI SGMELSEDDF NRLWQELTEI LVALGGERNK
ISERLNSIVD PEQEAEYFTL LDQLYKEDME VKDLARGGSL RQLKKFDPAE TIEDLIRNNY
TLLRKRLQVE KLIPHFIERR LLDFPEDKQV AMSKTTTPGK AEALLELLIQ KGTCTTEEFV
EILKKGDHQH VADQLKRTDT HSKTTKVCED LNLHLGEVYT NPQLQRRDGR ERFQDTDTIV
SLADIYHTSI GVDSQASSVV RKVRVEGDPG IGKSCSCQKL AYDWASGKLD RFKVVFFLEM
RHIAGKVQDE IFEQLLPKDT KNTPDHLWSY IQENEDDVLF ILDGLDELSQ AAREVTDVVD
LIQGKILRNC RVLVTSRPYH CVVDLEKCHQ FYKIVGYSRE NSEMFIHKYF SSSPESASKL
IKELHSNSNL SEIVVNPLNN VLICVVWEDN NNELPSGKDD LYRDIVDSVA KRFCKKRSIA
IEGDKLPPHI EEALRGLEKL SWEGLEQEQL QFNIDEITKK YQETADNMLN MGLLTRDYSF
SRIKRTYYCA FLHKTFQEYM AARYISGLVM DGSSREQGMK CVCRLFGMSD AIVDNRGMVM
SCQRKYKEKF AAGYVSDVHA TAMALSKPSS PDPVYTPDSA ETIEDLIRKN YTLLRKRLQV
EKLIPHFIER KLLDFPEDKQ VAMSKTTAPG KAEALLELLT QKGTCTPEEF VEILKKGDHR
HVADQLKRTG THSKTTKGPS DLTDDVIDCL KDLYATEYAH VRPLPWCEDF NLHLGEVFTN
LQLQYKDGRG RFQNTETIVS LADIYSTIAS EGEDEISQVN VRSDVRKVRV EGDPGIGKSC
SCQKLAYDWA SGKLDRFKVV FFLEMRHLAG KIKDEIFEQL LPKDAKNTPD QLWSYIQENQ
DDVLFILDGL DELSQAAREA TDVVDLIQGK ILRNCHVLVT SRPYHCVKDL EKCHQFYKIV
GYSRKNSLVF IHKYFSNSPE SASKLINQLY SNRNLSKIIV NPLNNVLICV VWEDNNKNLP
SYKDELYRDI VHSVAKRFCK KRDPDMEVEG DQLTPDVEDA LRNLGKLSWE GLEQDQLQFN
IEEITKKYGT TADNMLNMGL LTRDYSFSRI KRTCYCTFLH KKFQEYMAAR YISGLVVDGS
SREEGMKCVC RLFGMSDDTV ENRELIITCY RKYREVQNWL LLILGENSRP LFEKFAKELS
KAQTDEDREV LSCLCILWLG TSCAGGKMAE IVAHCLSQHA TNNVYNFDDN KEDLRFYHDD
HFNWCVGLAH VLTYQKELPV SHGTSVIQHL TVNCPLVRAS QEKLDVLENA LSDYDAMRSV
TFLGTGIDTC SLRTYIPRCG TESVIIHSKG VVNYLSLLST LEQLSAVARI EHVTAEFFIS
IDANPGERHI EFSEFDRLLA RMIKRHTRLR SLRLMICCLM TMRKDTKAKI FSNLTATLQS
ISEHTRLEVV DFKFPGECDL AIIEDASECA ENQHETINVE PMVHKLTECV KKNKVLKKLR
LRWRSSCIKG NRNKMYVYHG DCSSQALSNL CSAIRENRTL ETLVVEGMLS HTECRAEMIS
ELIRNKPSNY KELSITFSNS HAQSLKQGLV LQANDKVTSI SYKDRLMYSK QV
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