ID C3YPK4_BRAFL Unreviewed; 329 AA.
AC C3YPK4;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 60.
DE SubName: Full=2'-5'-oligoadenylate synthase-like protein 2 {ECO:0000313|RefSeq:XP_035675454.1};
GN Name=LOC118415180 {ECO:0000313|RefSeq:XP_035675454.1};
GN ORFNames=BRAFLDRAFT_121175 {ECO:0000313|EMBL:EEN57788.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN57788.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN57788.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN57788.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
RN [2] {ECO:0000313|RefSeq:XP_035675454.1}
RP IDENTIFICATION.
RC STRAIN=S238N-H82 {ECO:0000313|RefSeq:XP_035675454.1};
RC TISSUE=Testes {ECO:0000313|RefSeq:XP_035675454.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the 2-5A synthase family.
CC {ECO:0000256|ARBA:ARBA00009526}.
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DR EMBL; GG666538; EEN57788.1; -; Genomic_DNA.
DR RefSeq; XP_002601776.1; XM_002601730.1.
DR RefSeq; XP_035675454.1; XM_035819561.1.
DR STRING; 7739.C3YPK4; -.
DR KEGG; bfo:118415180; -.
DR eggNOG; ENOG502RH25; Eukaryota.
DR InParanoid; C3YPK4; -.
DR OMA; CEFNTAQ; -.
DR OrthoDB; 5390172at2759; -.
DR Proteomes; UP000001554; Chromosome 5.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0001730; F:2'-5'-oligoadenylate synthetase activity; IBA:GO_Central.
DR GO; GO:0003725; F:double-stranded RNA binding; IBA:GO_Central.
DR CDD; cd05400; NT_2-5OAS_ClassI-CCAase; 1.
DR Gene3D; 1.10.1410.20; 2'-5'-oligoadenylate synthetase 1, domain 2; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR InterPro; IPR018952; 2-5-oligoAdlate_synth_1_dom2/C.
DR InterPro; IPR006116; NT_2-5OAS_ClassI-CCAase.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR PANTHER; PTHR11258; 2-5 OLIGOADENYLATE SYNTHETASE; 1.
DR PANTHER; PTHR11258:SF11; MATH DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01909; NTP_transf_2; 1.
DR Pfam; PF10421; OAS1_C; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81631; PAP/OAS1 substrate-binding domain; 1.
DR PROSITE; PS50152; 25A_SYNTH_3; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Reference proteome {ECO:0000313|Proteomes:UP000001554}.
FT DOMAIN 54..87
FT /note="Polymerase nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF01909"
FT DOMAIN 167..325
FT /note="2'-5'-oligoadenylate synthetase 1"
FT /evidence="ECO:0000259|Pfam:PF10421"
SQ SEQUENCE 329 AA; 37526 MW; 694DEE14E32F36F8 CRC64;
MPYFSGASFL QLTSERDLNA HIDSELQMTE SDRVRYNKVL DGLYRTLQTE VRYNNVTVNR
LVKGGSYGRG TALKDRSDLD VTLFLNGISS MADFRGQQSS IIDRVATTLE RSSWARENGV
ARVIAQPNAA TLVLERGNHR MEVDIVPAYD NLGAVSNPML RNEVYQSMRG QDPYKYSASF
VGLQVEFVRD RPARLKNLIR LVKSWKKAQD ERFTRERGSK TKLGSSWLWE LICIYVCETK
VGSTSSFNMR QAFKMVMQTA VNYSSLQAWW KTYYSDRFPV VREKLSSTGS PLVLDPANPW
DNVADRCKHW CLVEQAAREA LQSPLLAYV
//