ID C3Z055_BRAFL Unreviewed; 851 AA.
AC C3Z055;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN ORFNames=BRAFLDRAFT_85680 {ECO:0000313|EMBL:EEN54114.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN54114.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN54114.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN54114.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the TRIM/RBCC family.
CC {ECO:0000256|ARBA:ARBA00008518}.
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DR EMBL; GG666567; EEN54114.1; -; Genomic_DNA.
DR RefSeq; XP_002598102.1; XM_002598056.1.
DR AlphaFoldDB; C3Z055; -.
DR eggNOG; KOG2177; Eukaryota.
DR InParanoid; C3Z055; -.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd19756; Bbox2; 2.
DR CDD; cd05819; NHL; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 2.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001258; NHL_repeat.
DR InterPro; IPR047153; TRIM45/56/19.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR25462; BONUS, ISOFORM C-RELATED; 1.
DR PANTHER; PTHR25462:SF229; NHL (RING FINGER B-BOX COILED COIL) DOMAIN CONTAINING; 1.
DR Pfam; PF01436; NHL; 2.
DR Pfam; PF00643; zf-B_box; 2.
DR Pfam; PF13445; zf-RING_UBOX; 2.
DR SMART; SM00336; BBOX; 2.
DR SMART; SM00184; RING; 2.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 2.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR SUPFAM; SSF57850; RING/U-box; 2.
DR PROSITE; PS51125; NHL; 3.
DR PROSITE; PS50119; ZF_BBOX; 2.
DR PROSITE; PS00518; ZF_RING_1; 2.
DR PROSITE; PS50089; ZF_RING_2; 2.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 18..58
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 98..139
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 303..343
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 383..424
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT REPEAT 591..631
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REPEAT 729..767
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REPEAT 769..812
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REGION 570..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 851 AA; 94657 MW; B0605967537CD0C3 CRC64;
MAAASSSLGT DFKEELSCCI CLELFTRPKV LPCGHIFCQG CLQNLTRSGG AFKCPICRQQ
VRLPHHGVSC LPDSHNIANM CEKLRQNSSS EETREQPQSG NRCSFHPSEM IKVFCKQCQI
PVCDHCLNEA HDDHHIATIK KAAQEKSLLV RSLINEGKNI MESYLSLFRS LTERKDNFAK
KLNMIQTERD RVLEKVNKLS AACDQAEQEM EKGGVEFLSQ QTTLTEVVGK YRGKAAPTPV
QTQPAVFEPM DTTVPVLGHV RVQSLPSAPI PAVPAPIPAA PTSRTDAVWG KGHHHDFKEE
LSCCICLELF TRPKVLPCGH IFCQGCLQNL TRSGGAFKCP ICRQQVRLPH HGVSCLPDSH
NIANMCEKLR QNSSSEETRE QPQSGNRCSF HPSEMIKVFC KQCQIPVCDH CLNEAHDDHH
IATIKKAAQE KSLLVRSLIN EGKNIMESYL SLFRSLTERK DNFAKKLNMI QTERDRVLEK
VNKLSAACDQ AEQEMEKGGV EFLSQQTTLT EVVGKYRGKA APTPVQTQPA VFEPMDTTVP
VLGHVRVQSL PSAPIPAVPA PIPAAPTSRT DAVWGKGHHH GNQRQPQRVT FGGWGREAGQ
FRYPFGVTVS KEGEVFVADF ENQRIQVFTL WGTFVRQFPT VVSGGHRMRP WNIAMDREGN
LWVVGRADSA EFAVLYNKLG FRQHTIDLQK SASQRGIAVD TRRNHLLITQ TTADGYNMYG
EVLAFRLDGT VGRQQGMKQP WYITVDGEGN ILVSDVRNHC VYVYKEYGQF QFGSRGSGVG
ELCNPHGICT DSAGNIIVAD SGNSRLVLFD KTGRCLKQVT TDMRMPLAVA VAPQGKLVVT
DFQEHTVNIF F
//
