ID C3Z1L0_BRAFL Unreviewed; 1248 AA.
AC C3Z1L0;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 69.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EEN53628.1};
GN ORFNames=BRAFLDRAFT_82284 {ECO:0000313|EMBL:EEN53628.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN53628.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN53628.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN53628.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG666573; EEN53628.1; -; Genomic_DNA.
DR RefSeq; XP_002597616.1; XM_002597570.1.
DR AlphaFoldDB; C3Z1L0; -.
DR eggNOG; KOG1480; Eukaryota.
DR eggNOG; KOG3523; Eukaryota.
DR InParanoid; C3Z1L0; -.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01221; PH_ephexin; 1.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR047271; Ephexin-like.
DR InterPro; IPR047270; PH_ephexin.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12845:SF5; EPHEXIN, ISOFORM D; 1.
DR PANTHER; PTHR12845; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF00791; ZU5; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00454; SAM; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 1.
PE 4: Predicted;
FT DOMAIN 142..209
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 270..452
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 766..907
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1091..1164
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 1..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1037..1058
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1171..1248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..31
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..57
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1037..1055
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1172..1200
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1225..1248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1248 AA; 138841 MW; BB4C28F30B469CAC CRC64;
MSQSLRPLSP LKTSGSADST PPPPPRSPLK PPGSADSTGT GTATDKHIHH VRGGEKPATF
PRLENLNRTK SNQYSKLKLP AFDDGVTSRS SGSEAPSAGK SSLGTRRTSL PTPTGATKTF
RQTSVPSMDD PEGPDQEVVR HWTRKDVKAW IKASWPKHLT TYRKKFYSKK IDGEALLALT
EERLAEELKV QQPEDRSAIM ELVKTLRTAG SKESFVDEQD EEMFHAGPLY QNSEMQEEHQ
DTAGAEAHGA EAEAQGAGIM RGRTRSLWRN FSMAKYEVIS LHVSLLKSLK VLVDVFESDE
TLMGIMGQHN HRRLFAGTEG LMAMSRSLVK ELKQSFHRDV LMTEFLTLDT YNRYFMDYHT
YCRTAVYQQA LLQKLLQASG EFAVRIDQLE IYPRCCGNRL DSFLKIPQQH ITKLKTVFEG
ILRHAPKGSS EERSAYEIIK AMEKTIKTCE EAVAAMTESL ELQEKLTFRK TKEVEVASPD
RWLERVGEFS ELRGGRISSP EAPVLMFLFN DMILITRREA TDGLAVQDYA PRRLLEVLSV
GQALCRAFGM EDLYQITLAA NHRGVMEELV LHPETSDDVD LLLSVPVSDE QVSNDTDEDV
EYGVITESFS ITDTADKPIV FEEGDVVKIY GHMEDLETRV HAVRMTDGQV GVLPGHVIGM
VSGESGGYGS RERCTSATVV PKNLSTTQRD PVITTRVPSM VLVPRVPSLV RTKTKGSSLG
GSDGNQSPNT SISEYSHFDA LWSLAQERLD ASVNDSSDKF NVVSSNFAAG VFDELGGHLS
ILEKGISLFI PPGAIAGGPT KIYIYLESID VHQDETLPEG QAMMSSTLYC GPPGTQFDED
VVFTLPYQGS GCDAMWNLFP VQTQTAVGET PDWRSLTDDD QAMHFLSNGF CTYFVSHFTG
FGVVGDCSRS DGARVKIFRF GAFASPREMR GRSRRRVLQL EESEHCGKLI DAHRPLPLRE
GRGDVCMAAT DTAAGWQLRG CGEQSIPEIL LWMEEEEPVD SSCTFEFHTT NDKPGRFGCT
VKIYQEETPK TLVRLNASDS EETQQESSSG PTNEPPNLRF LRLQPELQPI KQDGALLPPS
AHRQICAVLD VHSPLGNDWR AFAEKLGLPF DTICWVEGKR PTARLLYYWE HTNAGGGSLA
LRNLKQIFQE LEREDVTEIL SEVIPLYSND PESYRKGRRS TEPSDSGRNE RADKEQCSPR
KFSDSVITMA TEDRSRMLKK GGSKDNLDVQ SSRVSQRLSE STRAISVF
//
