ID   C3Z6Q7_BRAFL            Unreviewed;       314 AA.
AC   C3Z6Q7;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   28-JUN-2023, entry version 51.
DE   RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN   ORFNames=BRAFLDRAFT_69123 {ECO:0000313|EMBL:EEN51503.1};
OS   Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC   Branchiostomatidae; Branchiostoma.
OX   NCBI_TaxID=7739;
RN   [1] {ECO:0000313|EMBL:EEN51503.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN51503.1};
RC   TISSUE=Testes {ECO:0000313|EMBL:EEN51503.1};
RX   PubMed=18563158; DOI=10.1038/nature06967;
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA   Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA   Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA   Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA   Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA   Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA   Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA   Satoh N., Rokhsar D.S.;
RT   "The amphioxus genome and the evolution of the chordate karyotype.";
RL   Nature 453:1064-1071(2008).
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DR   EMBL; GG666590; EEN51503.1; -; Genomic_DNA.
DR   RefSeq; XP_002595491.1; XM_002595445.1.
DR   AlphaFoldDB; C3Z6Q7; -.
DR   InParanoid; C3Z6Q7; -.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR017241; Toll-like_receptor.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR24365:SF541; MSTPROX-RELATED; 1.
DR   PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR   Pfam; PF01582; TIR; 1.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   4: Predicted;
FT   DOMAIN          141..277
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   314 AA;  35103 MW;  BA713877BAF307EB CRC64;
     MTCGLGEGSV RQHGVQVKLW RYQGHRIIFH CILRTNGGLQ NEDVAIDVIV DPPPQNRKPA
     SSPVIVPDVS PIITFKQEQK VATDACPSMD GNSCAVNITS QIDSSFDAGT EFLGAVDGHV
     KELEEKIKAT GNSLEAPLKP RTYDCFIIYS RDNEDVVYNK LIPFFKKNNI KYCEHQEHFD
     LGKNIFDNVN TCITCSRRVV AVLSRSFFDS GYCKMDLDAA RGYAASSGYS LQDFLISIKI
     TDFVFPNKYS DISNSTYADL SEDVNDERKW LQIRKALTEF RLASVIMRIE MGSKYCTPKS
     KLAVPGANKI ETVV
//