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Database: UniProt
Entry: C3Z6V2_BRAFL
LinkDB: C3Z6V2_BRAFL
Original site: C3Z6V2_BRAFL 
ID   C3Z6V2_BRAFL            Unreviewed;      2041 AA.
AC   C3Z6V2;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   25-OCT-2017, entry version 52.
DE   RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   ORFNames=BRAFLDRAFT_64590 {ECO:0000313|EMBL:EEN51548.1};
OS   Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Branchiostomidae;
OC   Branchiostoma.
OX   NCBI_TaxID=7739 {ECO:0000313|Proteomes:UP000001554};
RN   [1] {ECO:0000313|EMBL:EEN51548.1, ECO:0000313|Proteomes:UP000001554}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN51548.1,
RC   ECO:0000313|Proteomes:UP000001554};
RC   TISSUE=Testes {ECO:0000313|EMBL:EEN51548.1};
RX   PubMed=18563158; DOI=10.1038/nature06967;
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA   Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA   Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J.,
RA   Gibson-Brown J.J., Grigoriev I.V., Horton A.C., de Jong P.J.,
RA   Jurka J., Kapitonov V.V., Kohara Y., Kuroki Y., Lindquist E.,
RA   Lucas S., Osoegawa K., Pennacchio L.A., Salamov A.A., Satou Y.,
RA   Sauka-Spengler T., Schmutz J., Shin-I T., Toyoda A.,
RA   Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA   Satoh N., Rokhsar D.S.;
RT   "The amphioxus genome and the evolution of the chordate karyotype.";
RL   Nature 453:1064-1071(2008).
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. This channel gives
CC       rise to T-type calcium currents. T-type calcium channels belong to
CC       the "low-voltage activated (LVA)" group and are strongly blocked
CC       by nickel and mibefradil. A particularity of this type of channels
CC       is an opening at quite negative potentials, and a voltage-
CC       dependent inactivation. T-type channels serve pacemaking functions
CC       in both central neurons and cardiac nodal cells and support
CC       calcium signaling in secretory cells and vascular smooth muscle.
CC       They may also be involved in the modulation of firing patterns of
CC       neurons which is important for information processing as well as
CC       in cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; GG666590; EEN51548.1; -; Genomic_DNA.
DR   RefSeq; XP_002595536.1; XM_002595490.1.
DR   STRING; 7739.JGI64590; -.
DR   PRIDE; C3Z6V2; -.
DR   GeneID; 7213293; -.
DR   KEGG; bfo:BRAFLDRAFT_64590; -.
DR   eggNOG; KOG2302; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   InParanoid; C3Z6V2; -.
DR   OMA; SPSVNCT; -.
DR   Proteomes; UP000001554; Partially assembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF00520; Ion_trans; 3.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01629; TVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001554};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001554};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     35     57       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    427    445       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    457    478       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    490    506       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    548    570       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    591    607       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    627    650       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    971    989       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1009   1030       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1106   1128       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1207   1232       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1292   1310       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1325   1348       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1360   1379       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1422   1445       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1514   1539       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      426    660       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      970   1242       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1290   1544       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     1239   1268       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2041 AA;  228538 MW;  32AA01AD66573420 CRC64;
     MNLTTNCINW NQYYTECKEG LHNPFKDAIS FDNILYAWVA IFQIGSFFMI NLCLVVIATQ
     FSETKQRESR LMEEQRRKYL STSTLSSQPN PDHPRGCYEE VFKLCVHMCK RLRRRVLRLY
     HRFQGRHQRK VDPALTLQRK RRRRKKSVCV HHHHHHHHHH YHFGGATNPL PPIQSSPPKY
     QVTLSQSPCP SPLAPIATPE PSDVESLQSP SKSNLLRVPS TNGVHRSRES LQSSHSDAAT
     NGEPDTTLRK SSLLPPLKDV NVPSPKHLSV PLPAIATPGV KVLPPLKSRP PVEELQTLAV
     ASTKNIARAV TQSCHSSPGP STKPVTSDPN IFQEDNDQSL QVQRLSVPSV IPSSLQVPAV
     VSKDHVECTC THTQLDWGSN SESEVSVSDE ELDSKKYRDE SVDLPPRPPG CWERFTKFMR
     TIVDSKYFNR GIMVAILVNT LSMGIEFHNQ PEELTNALEI SNLVFTSLFA LEMLLKLLAY
     GPLEYIRNGF NVFDGIIVIV SIVEIAEDGE GGLSVLRTFR LMRILKLIRF LPALRRQLLV
     MIKTMDNVAT FFALLILFIF IFSILGMHLF GNKFCEPDPV HNKKVTCDRK NFDTLLWALV
     TVFQILTQED WNLVLYNGMK NTSPWAALYF IALMTFGNYV LFNLLVAILV EGFSAEEERK
     SEMDDSNSQL AGPSNYKMVL VGAARKDGDG DDTSPNVLNN ERTLVVAGPE PPIITRTEAT
     PQGSPNTDGP SNGKSVSYPA SVSSQEDDSS PGNPSALTVP EQDSPGLSRS GSRSSHFSWR
     RSKGGERESI LFADDEDNLN DEVFTNTTHT YEEDGTIRSS FNPQEAASQS GSLRSRNVAG
     RTRESTTSQG SDCSHLSVNS KPGNNGNNGN SPRVSVSSEC NGGPRLSVVD KPVLMVEVDK
     EKDTEVNGPP DVVVLKDPTD KKVACPEKSI YWKCCPAPKG CFKTRAYYSL FLFSPENRLR
     LFCQYLVNKK WFDYVILIFI FMNCITLAME RPKIDPDSGE RMFLTIANYV FTVIFTLEMS
     VKVLALGFVF GEGAYLKSGW NVIDGFLVAI SLADTVIMLS SNSSPKIFGI LRVFRLLRTL
     RPLRVISRAP GLKLVVQTLL SSLKPIGNIV LICCTFFVIF GILGVQLFKG KFFHCEGPDL
     YGVKNKTDCL KDTKRKWVNQ KYNFDNLGQA LMALFVLASK DGWVDIMYNG LDAVDIDVQP
     IENYNEWMII FFISFLLLVG FFVLNMFVGV VVENFHKCRE DAEREERLAQ EERRRKKMER
     RLRREADSDD ELFYMRYSKP RRLVYDLITN KYFDLCIAAI IGVNVISMAI EHHDMKEELF
     RVLQYINYVF TAIFILEAAL KITGLGFVRY IKERWNQLDM LIVILSIVGI VLEEMDATFL
     PINPTIIRIM RVLRIARVLK LLKMAKGIRS LLETVMKALP QVGNLGLLFF LLFFIFAALG
     VELFGKIDCT SNVERPCSGL GLHANFKNFS MALLTLFRIA TGDNWNGIMK DTLRGPPDCD
     DSENCKANCC VSAILAPIYF VSFVLMAQFV LVNVVVAVLM KNMEDSVVKE LSKGRSSESW
     RMSRGRPTDR CCEGAVKRKE FRELEDEQGA TNGQVRGIWQ SSGVVKEATT MAMLKDKQGA
     TNGQGNGDGK KRVTRFHSLP DSFTFPVGAQ SRENSGGSSD NKDLLYTISP SKVSLIFHEE
     DEKDNRYTGD IEMRTFSLAH NNHEDTLQET ILGVKFKNKK RTRKDAKDKT ETEPMLADDN
     SCTSNTSSPV AYSDQVPPSY DEVQVNSSPS VEEIRISDYG EKDLPSLSWT SSIEDNRLDE
     EVAHLTDASF GDKFRRASTP VNMHASDQTT GFRCVMGSSV DIRGDQSPML QRQGTQGSIS
     AQDLSRSDSA SVSAGRSTNT LLGSSQHVPT CSSRDTLQSD TTLQTRNNST DLLSSPHRLS
     VPSLHAQGST LLSRCHKLSN SVGVISEVPD SRERSRSGKD RRSVCSLDPR VFQALNEAAS
     SRQGKPTPNG QNTPESRESM LQAHGTDVKQ RKQSNTQNLL GSQEHMQISP DSRHISKQDN
     V
//
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